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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2010-6-11
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pubmed:abstractText |
The prevalence of thiopurine S-methyltransferase (TPMT) polymorphism and its association with clinical and hematological toxicities was retrospectively analyzed in 71 Indian children with acute lymphoblastic leukemia (ALL). Only heterozygous TPMT alleles were observed (10%, 7/71) with relative frequencies being *1/*3C (4.2%), *1/*2 (4.2%) and *1/*3A (1.4%). The median 6-mercaptopurine dose administered during the maintenance therapy was 31% lower among patients with heterozygous TPMT alleles versus the rest (32.1mg/m(2)/day and 46.2mg/m(2)/day, p=0.005), though the myelosuppression and toxicities were similar in both the groups. Identification of TPMT genotype appears to be important in making the ALL treatment more effective and less toxic.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1873-5835
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pubmed:author |
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pubmed:copyrightInfo |
Copyright (c) 2010 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
34
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1023-6
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pubmed:meshHeading |
pubmed-meshheading:20153897-6-Mercaptopurine,
pubmed-meshheading:20153897-Antimetabolites, Antineoplastic,
pubmed-meshheading:20153897-Child,
pubmed-meshheading:20153897-Child, Preschool,
pubmed-meshheading:20153897-Dose-Response Relationship, Drug,
pubmed-meshheading:20153897-Female,
pubmed-meshheading:20153897-Genotype,
pubmed-meshheading:20153897-Humans,
pubmed-meshheading:20153897-India,
pubmed-meshheading:20153897-Infant,
pubmed-meshheading:20153897-Male,
pubmed-meshheading:20153897-Methyltransferases,
pubmed-meshheading:20153897-Polymorphism, Genetic,
pubmed-meshheading:20153897-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:20153897-Retrospective Studies,
pubmed-meshheading:20153897-Survival Rate,
pubmed-meshheading:20153897-Treatment Outcome
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pubmed:year |
2010
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pubmed:articleTitle |
Thiopurine S-methyltransferase gene polymorphism and 6-mercaptopurine dose intensity in Indian children with acute lymphoblastic leukemia.
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pubmed:affiliation |
Department of Pediatric Hematology and Oncology, Rajiv Gandhi Cancer Institute and Research Centre, Sector 5, Rohini, Delhi 110085, India. gauri kapoor2000@yahoo.com
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pubmed:publicationType |
Journal Article
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