Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2010-4-20
pubmed:abstractText
Seven new iodo-bridged binuclear platinum(II) complexes [Pt(L)I2]2 (1-7) (L=n-butylamine, isopropylamine, m-toluidine, p-toluidine, diethylamine, N-methylaniline and aniline) have been synthesized and characterized by elemental analysis, conductivity, thermal analysis, IR, 1H NMR and mass spectra techniques. The cytotoxicity was tested by MTT assay. The results indicate that they have selectivity against tested carcinoma cell lines. For example, the complexes (3 and 7) have better cytotoxicity than cisplatin against Bel-7402 cell line, the complexes (2-5 and 7) have better cytotoxicity than cisplatin against Hela cell line. The results suggest that the species of amine has important effect on cytotoxicity, when L=m-toluidine, p-toluidine and aniline, the complexes have better cytotoxicity against tested carcinoma cell lines.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1768-3254
pubmed:author
pubmed:copyrightInfo
Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2634-7
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Synthesis, characterization and cytotoxicity of iodo-bridged binuclear platinum(II) complexes.
pubmed:affiliation
College of Chemistry & Environmental Science, Chemical Biology Laboratory, Hebei University, and B-Ultrasound Room, Affiliated Hospital of Hebei University, Baoding 071002, China. jczhang6970@yahoo.com.cn
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't