Source:http://linkedlifedata.com/resource/pubmed/id/20153562
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
2010-4-20
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pubmed:abstractText |
Seven new iodo-bridged binuclear platinum(II) complexes [Pt(L)I2]2 (1-7) (L=n-butylamine, isopropylamine, m-toluidine, p-toluidine, diethylamine, N-methylaniline and aniline) have been synthesized and characterized by elemental analysis, conductivity, thermal analysis, IR, 1H NMR and mass spectra techniques. The cytotoxicity was tested by MTT assay. The results indicate that they have selectivity against tested carcinoma cell lines. For example, the complexes (3 and 7) have better cytotoxicity than cisplatin against Bel-7402 cell line, the complexes (2-5 and 7) have better cytotoxicity than cisplatin against Hela cell line. The results suggest that the species of amine has important effect on cytotoxicity, when L=m-toluidine, p-toluidine and aniline, the complexes have better cytotoxicity against tested carcinoma cell lines.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1768-3254
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pubmed:author | |
pubmed:copyrightInfo |
Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
45
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2634-7
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pubmed:meshHeading |
pubmed-meshheading:20153562-Antineoplastic Agents,
pubmed-meshheading:20153562-Cell Line, Tumor,
pubmed-meshheading:20153562-Drug Stability,
pubmed-meshheading:20153562-Humans,
pubmed-meshheading:20153562-Inhibitory Concentration 50,
pubmed-meshheading:20153562-Iodine,
pubmed-meshheading:20153562-Organoplatinum Compounds,
pubmed-meshheading:20153562-Spectrum Analysis,
pubmed-meshheading:20153562-Temperature
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pubmed:year |
2010
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pubmed:articleTitle |
Synthesis, characterization and cytotoxicity of iodo-bridged binuclear platinum(II) complexes.
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pubmed:affiliation |
College of Chemistry & Environmental Science, Chemical Biology Laboratory, Hebei University, and B-Ultrasound Room, Affiliated Hospital of Hebei University, Baoding 071002, China. jczhang6970@yahoo.com.cn
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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