Linked Life Data

20153472

Source:http://linkedlifedata.com/resource/pubmed/id/20153472

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2010-7-12
pubmed:abstractText
Association of estrogen receptor 1 (ESR1) gene variants and risk of coronary heart disease (CHD) and ischemic stroke was evaluated in the FINRISK-study. From 14,140 individuals, 2225 were selected for genotyping using a case-cohort design. Time-to-event analysis showed that the CC genotype of -397T/C ERS1 gene contributed to higher risk of CHD only in men (HR, 1.68, CI 1.03-2.74). The -351A/G polymorphism was not independently associated with CHD. Haplotype analysis of these two variants indicated that in men, haplotype TA conferred lower risk of CHD (HR=0.72, CI 0.55-0.95), whereas men with haplotype CA had 1.8 higher risk of CHD events (CI 1.21-2.77), compared to other haplotypes. No association was found with ischemic stroke. Our study suggests that the minor allele -397C of the ESR1 gene confers risk of CHD among Finnish men, both in homozygous state and as part of a haplotype with the -351A allele.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1879-1484
pubmed:author
pubmed:copyrightInfo
Copyright (c) 2010. Published by Elsevier Ireland Ltd.
pubmed:issnType
Electronic
pubmed:volume
211
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
200-2
pubmed:dateRevised
2011-4-21
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
ESR1 genetic variants, haplotypes and the risk of coronary heart disease and ischemic stroke in the Finnish population: a prospective follow-up study.
pubmed:affiliation
Department of Medical Biochemistry, Medical School, University of Tampere, and Research Unit of the Laboratory Centre, Tampere University Hospital, Tampere, Finland. tarja.kunnas@uta.fi
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't