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rdf:type |
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lifeskim:mentions |
umls-concept:C0021242,
umls-concept:C0205314,
umls-concept:C0220781,
umls-concept:C0220825,
umls-concept:C0243077,
umls-concept:C0599894,
umls-concept:C0679622,
umls-concept:C0913822,
umls-concept:C0913823,
umls-concept:C1707689,
umls-concept:C1883254
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pubmed:issue |
5
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pubmed:dateCreated |
2010-2-22
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pubmed:abstractText |
A series of indole ring containing compounds were designed based on the structure of the gp41 complex in the region of the hydrophobic pocket. These compounds were synthesized using a Suzuki Coupling reaction, and evaluated using a fluorescence binding assay and cell-cell fusion assay. The observed inhibition constant of compound 7 was 2.1microM, and the IC(50) for cell-cell fusion inhibition was 1.1microM. Assay data indicated that 7 is a promising lead compound for optimization into an effective low molecular weight fusion inhibitor.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20153190-10464007,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20153190-11341828,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20153190-11591141,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20153190-11741789,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20153190-12773651,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20153190-14703123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20153190-15518811,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20153190-15640162,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20153190-16540310,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20153190-16918361,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20153190-16963566,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20153190-17269924,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20153190-17452484,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20153190-17575260,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20153190-19053778,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20153190-19534533,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20153190-19632107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20153190-8723313,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20153190-9108481,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20153190-9707417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20153190-9861018
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1464-3405
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2010 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1500-3
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pubmed:dateRevised |
2011-7-25
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pubmed:meshHeading |
pubmed-meshheading:20153190-Anti-HIV Agents,
pubmed-meshheading:20153190-Benzoic Acids,
pubmed-meshheading:20153190-Binding Sites,
pubmed-meshheading:20153190-Cell Line,
pubmed-meshheading:20153190-Computer Simulation,
pubmed-meshheading:20153190-Drug Design,
pubmed-meshheading:20153190-HIV Envelope Protein gp41,
pubmed-meshheading:20153190-HIV Fusion Inhibitors,
pubmed-meshheading:20153190-Humans,
pubmed-meshheading:20153190-Indoles,
pubmed-meshheading:20153190-Thermodynamics
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pubmed:year |
2010
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pubmed:articleTitle |
Design, synthesis, and evaluation of indole compounds as novel inhibitors targeting Gp41.
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pubmed:affiliation |
Department of Basic Sciences, Touro University--California, 1310 Johnson Lane, Mare Island, Vallejo, CA 94592, United States. guangyan.zhou@tu.edu
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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