Source:http://linkedlifedata.com/resource/pubmed/id/20152244
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2010-2-15
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| pubmed:abstractText |
Previous studies have reported that increased high-sensitive C-reactive protein (hs-CRP) levels are associated with an inflammatory state. This study investigated the association among hs-CRP, substrate properties, and long-term clinical outcomes after catheter ablation of atrial fibrillation (AF). A total of 137 patients with AF (54 +/- 13 years) who underwent mapping and catheter ablation were included. The hs-CRP was measured before the first ablation procedure. The substrate properties (initiating triggers, biatrial mean voltage, and high-frequency sites) of the 2 atria and long-term outcome were investigated in patients in the low hs-CRP group (<75%, 2.92 mg/L) and high hs-CRP group (>75%, 2.92 mg/L). Patients with a higher hs-CRP were associated with an increased number of identified nonpulmonary vein ectopies (34.4% vs 17%, p = 0.034), lower mean left atrial (LA) voltage (1.72 +/- 0.73 vs 1.92 +/- 0.72 Hz, p = 0.045), and higher-frequency sites in the left atrium (71% vs 37%, p = 0.027). After a median follow-up period of 15 months, the single-procedure success rate (72% vs 53%, p = 0.008) and final success rate after multiple procedures (94% vs 81%, p = 0.02) were higher in the low hs-CRP group. In a multivariable regression model adjusted for other potential covariates, hs-CRP level (p = 0.021) and LA diameter (p = 0.032) were independent predictors of recurrence. In conclusion, baseline CRP levels before the first AF ablation procedure had an independent prognostic value in predicting long-term recurrence. Patients with a high hs-CRP level were associated with an abnormal LA substrate and high incidence of nonpulmonary vein AF sources.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Feb
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| pubmed:issn |
1879-1913
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| pubmed:author |
pubmed-author:ChangChien-JungCJ,
pubmed-author:ChangShih-LinSL,
pubmed-author:ChenShih-AnnSA,
pubmed-author:HuYu-FengYF,
pubmed-author:HuangShih-YuSY,
pubmed-author:LeePi-ChangPC,
pubmed-author:LinYenn-JiangYJ,
pubmed-author:LoLi-WeiLW,
pubmed-author:NguyenHuu TungHT,
pubmed-author:SuenariKazuyoshiK,
pubmed-author:TaiChing-TaiCT,
pubmed-author:TsaiWen-ChinWC,
pubmed-author:TsaoHsuan-MingHM,
pubmed-author:TuanTa-ChuanTC,
pubmed-author:UdyavarAmeya RAR
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| pubmed:copyrightInfo |
Copyright 2010 Elsevier Inc. All rights reserved.
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| pubmed:issnType |
Electronic
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| pubmed:day |
15
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| pubmed:volume |
105
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
495-501
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| pubmed:meshHeading |
pubmed-meshheading:20152244-Adult,
pubmed-meshheading:20152244-Aged,
pubmed-meshheading:20152244-Atrial Fibrillation,
pubmed-meshheading:20152244-Biological Markers,
pubmed-meshheading:20152244-C-Reactive Protein,
pubmed-meshheading:20152244-Catheter Ablation,
pubmed-meshheading:20152244-Electrocardiography,
pubmed-meshheading:20152244-Female,
pubmed-meshheading:20152244-Follow-Up Studies,
pubmed-meshheading:20152244-Heart Conduction System,
pubmed-meshheading:20152244-Humans,
pubmed-meshheading:20152244-Male,
pubmed-meshheading:20152244-Middle Aged,
pubmed-meshheading:20152244-Multivariate Analysis,
pubmed-meshheading:20152244-Predictive Value of Tests,
pubmed-meshheading:20152244-Prognosis,
pubmed-meshheading:20152244-Recurrence,
pubmed-meshheading:20152244-Risk Assessment,
pubmed-meshheading:20152244-Risk Factors,
pubmed-meshheading:20152244-Sensitivity and Specificity,
pubmed-meshheading:20152244-Treatment Outcome
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| pubmed:year |
2010
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| pubmed:articleTitle |
Prognostic implications of the high-sensitive C-reactive protein in the catheter ablation of atrial fibrillation.
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| pubmed:affiliation |
Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
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| pubmed:publicationType |
Journal Article
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