Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2010-2-15
pubmed:abstractText
During development of the central nervous system, precise synaptic connections between presynaptic and postsynaptic neurons are formed. While significant progress has been made in our understanding of AMPA receptor trafficking during synaptic plasticity, less is known about the molecules that recruit AMPA receptors to nascent synapses during synaptogenesis. Here we identify a type II transmembrane protein (SynDIG1) that regulates AMPA receptor content at developing synapses in dissociated rat hippocampal neurons. SynDIG1 colocalizes with AMPA receptors at synapses and at extrasynaptic sites and associates with AMPA receptors in heterologous cells and brain. Altered levels of SynDIG1 in cultured neurons result in striking changes in excitatory synapse number and function. SynDIG1-mediated synapse development is dependent on association with AMPA receptors via its extracellular C terminus. Intriguingly, SynDIG1 content in dendritic spines is regulated by neuronal activity. Altogether, we define SynDIG1 as an activity-regulated transmembrane protein that regulates excitatory synapse development.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/20152115-10195177, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152115-10195178, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152115-11140673, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152115-11931740, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152115-12040056, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152115-12049934, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152115-12196584, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152115-12408845, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152115-12626697, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152115-12767475, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152115-14556714, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152115-14684431, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152115-14735113, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152115-14749436, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152115-1500948, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152115-15169875, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152115-15772349, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152115-16022596, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152115-16359841, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152115-16504537, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152115-16513974, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152115-16630835, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152115-16870727, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152115-17046693, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152115-17122040, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152115-17299456, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152115-17329211, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152115-17417940, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152115-18655795, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152115-19265014, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152115-19607795, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152115-19914186, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152115-2032551, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152115-7506541, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152115-8938716, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152115-9285588, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152115-9618545, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152115-9856462
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1097-4199
pubmed:author
pubmed:issnType
Electronic
pubmed:day
14
pubmed:volume
65
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
80-93
pubmed:dateRevised
2011-7-20
pubmed:meshHeading
pubmed-meshheading:20152115-Amino Acid Sequence, pubmed-meshheading:20152115-Animals, pubmed-meshheading:20152115-Cell Line, pubmed-meshheading:20152115-Excitatory Postsynaptic Potentials, pubmed-meshheading:20152115-Female, pubmed-meshheading:20152115-Gene Expression Regulation, pubmed-meshheading:20152115-Hippocampus, pubmed-meshheading:20152115-Humans, pubmed-meshheading:20152115-Membrane Proteins, pubmed-meshheading:20152115-Molecular Sequence Data, pubmed-meshheading:20152115-Nerve Tissue Proteins, pubmed-meshheading:20152115-Neurons, pubmed-meshheading:20152115-Patch-Clamp Techniques, pubmed-meshheading:20152115-Pregnancy, pubmed-meshheading:20152115-Rats, pubmed-meshheading:20152115-Receptors, AMPA, pubmed-meshheading:20152115-Sequence Alignment, pubmed-meshheading:20152115-Sequence Homology, Amino Acid, pubmed-meshheading:20152115-Synapses
pubmed:year
2010
pubmed:articleTitle
SynDIG1: an activity-regulated, AMPA- receptor-interacting transmembrane protein that regulates excitatory synapse development.
pubmed:affiliation
Department of Pharmacology, School of Medicine, University of California, Davis, Davis, CA 95616, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.
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