Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2010-2-15
pubmed:abstractText
The density of GABA(A) receptors (GABA(A)Rs) at synapses regulates brain excitability, and altered inhibition may contribute to Huntington's disease, which is caused by a polyglutamine repeat in the protein huntingtin. However, the machinery that delivers GABA(A)Rs to synapses is unknown. We demonstrate that GABA(A)Rs are trafficked to synapses by the kinesin family motor protein 5 (KIF5). We identify the adaptor linking the receptors to KIF5 as the huntingtin-associated protein 1 (HAP1). Disrupting the HAP1-KIF5 complex decreases synaptic GABA(A)R number and reduces the amplitude of inhibitory postsynaptic currents. When huntingtin is mutated, as in Huntington's disease, GABA(A)R transport and inhibitory synaptic currents are reduced. Thus, HAP1-KIF5-dependent GABA(A)R trafficking is a fundamental mechanism controlling the strength of synaptic inhibition in the brain. Its disruption by mutant huntingtin may explain some of the defects in brain information processing occurring in Huntington's disease and provides a molecular target for therapeutic approaches.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/20152113-10036231, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152113-10359605, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152113-10846156, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152113-11050117, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152113-11085880, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152113-11092756, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152113-11144360, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152113-11416179, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152113-11713247, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152113-11906693, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152113-12514209, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152113-14527431, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152113-14527432, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152113-15242649, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152113-15310851, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152113-15606900, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152113-15629196, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152113-15882643, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152113-15944377, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152113-15968465, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152113-16120773, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152113-16192353, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152113-16510729, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152113-17060494, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152113-17158910, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152113-17188796, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152113-17409241, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152113-17925227, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152113-17928584, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152113-18184562, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152113-18442977, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152113-19249275, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152113-19374920, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152113-2974459, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152113-7477378, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152113-9281579, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152113-9361024, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152113-9454836, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152113-9714149, http://linkedlifedata.com/resource/pubmed/commentcorrection/20152113-9870948
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1097-4199
pubmed:author
pubmed:issnType
Electronic
pubmed:day
14
pubmed:volume
65
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
53-65
pubmed:dateRevised
2011-7-20
pubmed:meshHeading
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