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pubmed:abstractText |
Hyaluronic acid (HA) is present in many tissues; its presence in serum may be related to certain inflammatory conditions, tissue damage, sepsis, liver malfunction and some malignancies. In the present work, our goal was to investigate the significance of hyaluronic acid effect on erythrocyte flow properties. Therefore we performed in vitro experiments incubating red blood cells (RBCs) with several HA concentrations. Afterwards, in order to corroborate the pathophysiological significance of the results obtained, we replicated the in vitro experiment with ex vivo RBCs from diagnosed rheumatoid arthritis (RA) patients, a serum HA-increasing pathology.
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pubmed:affiliation |
Facultad de Ciencias Médicas, Universidad Nacional de Rosario, Cátedra de Física Biológica, Santa Fe 3100, 2000 Rosario, Argentina. luquitale@hotmail.com
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