rdf:type |
|
lifeskim:mentions |
umls-concept:C0005775,
umls-concept:C0011847,
umls-concept:C0026809,
umls-concept:C0030274,
umls-concept:C0033085,
umls-concept:C0061355,
umls-concept:C0087111,
umls-concept:C0205177,
umls-concept:C0205195,
umls-concept:C0442805,
umls-concept:C0532578,
umls-concept:C1292733,
umls-concept:C1527148,
umls-concept:C1958126
|
pubmed:issue |
3
|
pubmed:dateCreated |
2010-2-15
|
pubmed:abstractText |
Alogliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, and voglibose, an alpha-glucosidase inhibitor, have different but complementary mechanisms of action on glucagon-like peptide-1 (GLP-1) regulation and glucose-lowering effects. The present study evaluated the chronic effects of combination treatment with alogliptin and voglibose in prediabetic db/db mice.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Mar
|
pubmed:issn |
1463-1326
|
pubmed:author |
|
pubmed:issnType |
Electronic
|
pubmed:volume |
12
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
224-33
|
pubmed:dateRevised |
2011-6-1
|
pubmed:meshHeading |
pubmed-meshheading:20151999-Animals,
pubmed-meshheading:20151999-Diabetes Mellitus, Experimental,
pubmed-meshheading:20151999-Drug Therapy, Combination,
pubmed-meshheading:20151999-Hypoglycemic Agents,
pubmed-meshheading:20151999-Inositol,
pubmed-meshheading:20151999-Insulin-Secreting Cells,
pubmed-meshheading:20151999-Male,
pubmed-meshheading:20151999-Mice,
pubmed-meshheading:20151999-Mice, Inbred C57BL,
pubmed-meshheading:20151999-Piperidines,
pubmed-meshheading:20151999-Prediabetic State,
pubmed-meshheading:20151999-Transcription Factors,
pubmed-meshheading:20151999-Uracil
|
pubmed:year |
2010
|
pubmed:articleTitle |
Combination treatment with alogliptin and voglibose increases active GLP-1 circulation, prevents the development of diabetes and preserves pancreatic beta-cells in prediabetic db/db mice.
|
pubmed:affiliation |
Pharmacology Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Osaka, Japan. moritou_yuusuke@takeda.co.jp
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|