|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2010-5-3
|
|
pubmed:abstractText |
Intetumumab is a human IgG1 anti-alphav-integrin monoclonal antibody that inhibits angiogenesis. Integrin binding and angiogenesis are important in reproduction including fertilization, implantation, and embryofetal development. These studies were designed to determine the pharmacological relevance of the rabbit for the evaluation of potential effects on embryofetal development and to evaluate the placental transfer of intetumumab in rabbits.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
1542-9741
|
|
pubmed:author |
|
|
pubmed:copyrightInfo |
2010 Wiley-Liss, Inc.
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
89
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
116-23
|
|
pubmed:dateRevised |
2011-7-29
|
|
pubmed:meshHeading |
pubmed-meshheading:20151458-Amniotic Fluid,
pubmed-meshheading:20151458-Angiogenesis Inhibitors,
pubmed-meshheading:20151458-Animals,
pubmed-meshheading:20151458-Antibodies, Monoclonal,
pubmed-meshheading:20151458-Aorta, Thoracic,
pubmed-meshheading:20151458-Blood Vessels,
pubmed-meshheading:20151458-Cell Adhesion,
pubmed-meshheading:20151458-Cells, Cultured,
pubmed-meshheading:20151458-Embryo, Mammalian,
pubmed-meshheading:20151458-Embryonic Development,
pubmed-meshheading:20151458-Endothelial Cells,
pubmed-meshheading:20151458-Female,
pubmed-meshheading:20151458-Fetal Development,
pubmed-meshheading:20151458-Fetus,
pubmed-meshheading:20151458-Injections, Intravenous,
pubmed-meshheading:20151458-Integrin alpha5,
pubmed-meshheading:20151458-Maternal Exposure,
pubmed-meshheading:20151458-Maternal-Fetal Exchange,
pubmed-meshheading:20151458-Neovascularization, Physiologic,
pubmed-meshheading:20151458-Placenta,
pubmed-meshheading:20151458-Pregnancy,
pubmed-meshheading:20151458-Rabbits
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
Pharmacology and placental transfer of a human alphav integrin monoclonal antibody in rabbits.
|
|
pubmed:affiliation |
Centocor Research and Development, Inc., Radnor, Pennsylvania 19087, USA. pmarti27@its.jnj.com <pmarti27@its.jnj.com>
|
|
pubmed:publicationType |
Journal Article
|
