20147967

Source:http://linkedlifedata.com/resource/pubmed/id/20147967

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0006826, umls-concept:C0009221, umls-concept:C0025118, umls-concept:C0026882, umls-concept:C0027651, umls-concept:C0205422, umls-concept:C0555952
pubmed:issue	4
pubmed:dateCreated	2010-2-17
pubmed:abstractText	Response to EGFR-targeted therapies in colorectal cancer patients has been convincingly associated with Kirsten-Ras (K-Ras) mutation status. Current mandatory mutation testing for patient selection is limited to the K-Ras 'hotspot' codons 12 and 13.
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pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0370635
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Codon
pubmed:status	MEDLINE
pubmed:month	Feb
pubmed:issn	1532-1827
pubmed:author	pubmed-author:BoundsRR, pubmed-author:CareyF AFA, pubmed-author:SmithGG, pubmed-author:SteeleR J CRJ, pubmed-author:WolfC RCR, pubmed-author:WolfHH
pubmed:issnType	Electronic
pubmed:day	16
pubmed:volume	102
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	693-703
pubmed:dateRevised	2011-7-25
pubmed:meshHeading	pubmed-meshheading:20147967-Aged, pubmed-meshheading:20147967-Aged, 80 and over, pubmed-meshheading:20147967-Animals, pubmed-meshheading:20147967-Codon, pubmed-meshheading:20147967-Colorectal Neoplasms, pubmed-meshheading:20147967-Female, pubmed-meshheading:20147967-Gene Frequency, pubmed-meshheading:20147967-Genes, ras, pubmed-meshheading:20147967-Humans, pubmed-meshheading:20147967-Individualized Medicine, pubmed-meshheading:20147967-Male, pubmed-meshheading:20147967-Mice, pubmed-meshheading:20147967-Middle Aged, pubmed-meshheading:20147967-Models, Biological, pubmed-meshheading:20147967-Mutation, pubmed-meshheading:20147967-NIH 3T3 Cells, pubmed-meshheading:20147967-Patient Selection, pubmed-meshheading:20147967-Polymorphism, Single Nucleotide, pubmed-meshheading:20147967-Tumor Stem Cell Assay
pubmed:year	2010
pubmed:articleTitle	Activating K-Ras mutations outwith 'hotspot' codons in sporadic colorectal tumours - implications for personalised cancer medicine.
pubmed:affiliation	Biomedical Research Institute, Ninewells Hospital and Medical School, Dundee, UK.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't