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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2010-3-9
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pubmed:abstractText |
Despite intensive studies focused on the pathophysiology of asthmatic inflammation, little is known about how cross-talk between neuroendocrine and immune systems regulates the inflammatory response during an asthmatic attack. We recently showed corresponding changes of cytokines and leukotriene B4 (LTB4) in brain and lung tissues of antigen-challenged asthmatic rats. Here, we investigated how LTB4 interacts with the neuroendocrine-immune system in regulating antigen-induced asthmatic responses in sensitized guinea pigs.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1742-2094
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
12
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pubmed:dateRevised |
2010-9-28
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pubmed:meshHeading |
pubmed-meshheading:20146826-Adrenocorticotropic Hormone,
pubmed-meshheading:20146826-Analysis of Variance,
pubmed-meshheading:20146826-Animals,
pubmed-meshheading:20146826-Asthma,
pubmed-meshheading:20146826-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:20146826-Chromatography, Reverse-Phase,
pubmed-meshheading:20146826-Disease Models, Animal,
pubmed-meshheading:20146826-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:20146826-Fatty Alcohols,
pubmed-meshheading:20146826-Glycols,
pubmed-meshheading:20146826-Guinea Pigs,
pubmed-meshheading:20146826-Hydrocortisone,
pubmed-meshheading:20146826-Injections, Intraventricular,
pubmed-meshheading:20146826-Intracranial Hemorrhages,
pubmed-meshheading:20146826-Leukotriene B4,
pubmed-meshheading:20146826-Lung,
pubmed-meshheading:20146826-Ovalbumin,
pubmed-meshheading:20146826-Time Factors
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pubmed:year |
2010
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pubmed:articleTitle |
Leukotriene B4, administered via intracerebroventricular injection, attenuates the antigen-induced asthmatic response in sensitized guinea pigs.
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pubmed:affiliation |
Zhejiang Respiratory Drugs Research Laboratory of State Food and Drug Administration of China, Medical Science College of Zhejiang University, Hangzhou, China.
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