rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2010-2-11
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pubmed:abstractText |
For patients with borderline personality disorder (BPD), we previously reported an independent effect of the catechol-o-methyl-transferase (COMT) low-activity (Met(158)) allele and an interaction with the low-expression allele of the deletion/insertion (short/long or S/L, resp.) polymorphism in the serotonin transporter-linked promoter region (5-HTTLPR). The purpose of the present study was to extend these findings to the tyrosine hydroxylase (TH) Val(81)Met single nucleotide polymorphism (SNP), the 5-HTTLPR S/L polymorphism incorporating the recently described functional A/G SNP within the long allele of the 5-HTTLPR (rs25531) as well as the variable number of tandem repeat (VNTR) polymorphism within intron 2 of the serotonin transporter gene (STin2).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1814-1412
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
45-58
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pubmed:meshHeading |
pubmed-meshheading:20146650-Alleles,
pubmed-meshheading:20146650-Borderline Personality Disorder,
pubmed-meshheading:20146650-Case-Control Studies,
pubmed-meshheading:20146650-Catechol O-Methyltransferase,
pubmed-meshheading:20146650-Diagnostic and Statistical Manual of Mental Disorders,
pubmed-meshheading:20146650-Genetic Variation,
pubmed-meshheading:20146650-Genome-Wide Association Study,
pubmed-meshheading:20146650-Genotype,
pubmed-meshheading:20146650-Humans,
pubmed-meshheading:20146650-Polymorphism, Single Nucleotide,
pubmed-meshheading:20146650-Serotonin Plasma Membrane Transport Proteins,
pubmed-meshheading:20146650-Tyrosine 3-Monooxygenase
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pubmed:year |
2010
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pubmed:articleTitle |
Association analysis between gene variants of the tyrosine hydroxylase and the serotonin transporter in borderline personality disorder.
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pubmed:affiliation |
Department of Psychiatry and Psychotherapy, University Medical Center Mainz, Germany. tadic@uni-mainz.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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