Source:http://linkedlifedata.com/resource/pubmed/id/20144742
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
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| pubmed:dateCreated |
2010-4-13
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| pubmed:abstractText |
Xanthohumol (XN) and its related compounds were evaluated for their effects on modulating the production of interleukin (IL)-12, the most important factor driving T helper 1 immune responses. XN showed the strongest inhibitory effect on IL-12 production in macrophages stimulated by lipopolysaccharide (LPS) or LPS/interferon-gamma. Xanthohumol 4'-O-beta-D-glucopyranoside (XNG) inhibited IL-12 production less effectively than XN. Isoxanthohumol and 8-prenylnaringenin showed comparatively lower inhibitory effects on IL-12 production than XNG. (2S)-5-methoxy-8-prenylnaringenin 7-O-beta-D-glucopyranoside did not exert any effect on IL-12 production. We then tested how these compounds affected NF-kappaB binding activity to the kappaB site in the nucleus. The compounds inhibited kappaB binding in macrophages with the same potency order as IL-12 inhibition. Furthermore, we investigated whether XN, which showed the most effective reduction of IL-12 production, attenuated skin inflammation. Chronic allergic contact dermatitis, an experimental model for psoriasis, was used to determine the anti-inflammatory effects of XN in vivo. XN treatment reduced the degree of ear thickening induced by oxazolone. Taken together, XN might be effective as an anti-inflammatory agent to reduce skin inflammation by inhibiting IL-12 production.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Flavonoids,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-12,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Oxazolone,
http://linkedlifedata.com/resource/pubmed/chemical/Propiophenones,
http://linkedlifedata.com/resource/pubmed/chemical/xanthohumol
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| pubmed:status |
MEDLINE
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| pubmed:month |
May
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| pubmed:issn |
1878-1705
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 2010 Elsevier B.V. All rights reserved.
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| pubmed:issnType |
Electronic
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| pubmed:volume |
10
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
556-61
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| pubmed:meshHeading |
pubmed-meshheading:20144742-Animals,
pubmed-meshheading:20144742-Cells, Cultured,
pubmed-meshheading:20144742-Chronic Disease,
pubmed-meshheading:20144742-Dermatitis, Allergic Contact,
pubmed-meshheading:20144742-Female,
pubmed-meshheading:20144742-Flavonoids,
pubmed-meshheading:20144742-Humans,
pubmed-meshheading:20144742-Interferon-gamma,
pubmed-meshheading:20144742-Interleukin-12,
pubmed-meshheading:20144742-Lipopolysaccharides,
pubmed-meshheading:20144742-Macrophage Activation,
pubmed-meshheading:20144742-Macrophages,
pubmed-meshheading:20144742-Mice,
pubmed-meshheading:20144742-Mice, Inbred BALB C,
pubmed-meshheading:20144742-Mice, Inbred C57BL,
pubmed-meshheading:20144742-Models, Animal,
pubmed-meshheading:20144742-NF-kappa B,
pubmed-meshheading:20144742-Oxazolone,
pubmed-meshheading:20144742-Propiophenones,
pubmed-meshheading:20144742-Protein Binding,
pubmed-meshheading:20144742-Psoriasis
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| pubmed:year |
2010
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| pubmed:articleTitle |
Xanthohumol inhibits IL-12 production and reduces chronic allergic contact dermatitis.
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| pubmed:affiliation |
College of Pharmacy & Research Institute of Drug Development, Chonnam National University, Gwangju 500-757, Republic of Korea.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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