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rdf:type |
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lifeskim:mentions |
umls-concept:C0011209,
umls-concept:C0020456,
umls-concept:C0020615,
umls-concept:C0021641,
umls-concept:C0026336,
umls-concept:C0031809,
umls-concept:C0035647,
umls-concept:C0439583,
umls-concept:C0679083,
umls-concept:C0681890,
umls-concept:C2587213,
umls-concept:C2603343
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pubmed:issue |
5
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|
pubmed:dateCreated |
2010-2-10
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pubmed:abstractText |
Hypoglycemia and hyperglycemia during closed-loop insulin delivery based on subcutaneous (SC) glucose sensing may arise due to (1) overdosing and underdosing of insulin by control algorithm and (2) difference between plasma glucose (PG) and sensor glucose, which may be transient (kinetics origin and sensor artifacts) or persistent (calibration error [CE]). Using in silico testing, we assessed hypoglycemia and hyperglycemia incidence during over-night closed loop. Additionally, a comparison was made against incidence observed experimentally during open-loop single-night in-clinic studies in young people with type 1 diabetes mellitus (T1DM) treated by continuous SC insulin infusion.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1932-2968
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pubmed:author |
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pubmed:copyrightInfo |
2009 Diabetes Technology Society.
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pubmed:issnType |
Electronic
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1109-20
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:20144424-Adolescent,
pubmed-meshheading:20144424-Algorithms,
pubmed-meshheading:20144424-Blood Glucose,
pubmed-meshheading:20144424-Blood Glucose Self-Monitoring,
pubmed-meshheading:20144424-Computer Simulation,
pubmed-meshheading:20144424-Diabetes Mellitus, Type 1,
pubmed-meshheading:20144424-Diagnosis, Computer-Assisted,
pubmed-meshheading:20144424-Dietary Carbohydrates,
pubmed-meshheading:20144424-Drug Therapy, Computer-Assisted,
pubmed-meshheading:20144424-Female,
pubmed-meshheading:20144424-Humans,
pubmed-meshheading:20144424-Hyperglycemia,
pubmed-meshheading:20144424-Hypoglycemia,
pubmed-meshheading:20144424-Hypoglycemic Agents,
pubmed-meshheading:20144424-Infusions, Subcutaneous,
pubmed-meshheading:20144424-Insulin,
pubmed-meshheading:20144424-Insulin Infusion Systems,
pubmed-meshheading:20144424-Male,
pubmed-meshheading:20144424-Models, Biological,
pubmed-meshheading:20144424-Models, Statistical,
pubmed-meshheading:20144424-Pancreas, Artificial,
pubmed-meshheading:20144424-Predictive Value of Tests,
pubmed-meshheading:20144424-Risk Assessment,
pubmed-meshheading:20144424-Severity of Illness Index,
pubmed-meshheading:20144424-Systems Integration,
pubmed-meshheading:20144424-Treatment Outcome
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pubmed:year |
2009
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pubmed:articleTitle |
Overnight closed-loop insulin delivery with model predictive control: assessment of hypoglycemia and hyperglycemia risk using simulation studies.
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pubmed:affiliation |
Cambridge University Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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