|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
8
|
|
pubmed:dateCreated |
1991-5-15
|
|
pubmed:abstractText |
Nonspecific cytotoxic cells (NCC) in teleost fish are analogous to human natural killer (NK) cells and spontaneously lyse a variety of transformed human cell lines sensitive to human NK cell lysis. Monoclonal antibodies (mAbs) made against these NK-like effector cells inhibited their lytic activity. These anti-NCC mAbs were examined with human NK cells for their effects. It was observed that these mAbs bound specifically to a small percentage of peripheral blood lymphocytes (5-15%) and to the majority (greater than 85%) of CD3- NK cells. The mAbs inhibited human NK cell lysis against a variety of transformed cell lines. Single-cell assays showed that the mAbs exerted their effects through inhibition of conjugate formation (recognition). However, the mAbs did not inhibit NK cell-mediated antibody-dependent cell-mediated cytotoxicity. Biochemical analysis of the NK cell molecule revealed that a dimeric structure was involved (distinct from antigen receptors on T cells). Thus, this molecule appears to be a candidate NK cell antigen receptor.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2014223-2410507,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2014223-2433333,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2014223-2454262,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2014223-2528593,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2014223-310861,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2014223-351618,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2014223-3540123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2014223-3755221,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2014223-3905966,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2014223-6170683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2014223-6203780,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2014223-6219848,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2014223-6225799,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2014223-6334855,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2014223-6519339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2014223-6605197,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2014223-6734870,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2014223-7334070
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0027-8424
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
88
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
3009-13
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:2014223-Antibodies, Monoclonal,
pubmed-meshheading:2014223-Antibody-Dependent Cell Cytotoxicity,
pubmed-meshheading:2014223-Antigens, Surface,
pubmed-meshheading:2014223-Cytotoxicity, Immunologic,
pubmed-meshheading:2014223-Humans,
pubmed-meshheading:2014223-Immunity, Cellular,
pubmed-meshheading:2014223-Killer Cells, Natural,
pubmed-meshheading:2014223-Molecular Weight,
pubmed-meshheading:2014223-Precipitin Tests,
pubmed-meshheading:2014223-Receptors, Immunologic,
pubmed-meshheading:2014223-Signal Transduction
|
|
pubmed:year |
1991
|
|
pubmed:articleTitle |
Identification of an evolutionarily conserved, function-associated molecule on human natural killer cells.
|
|
pubmed:affiliation |
Department of Microbiology and Immunology, University of Arizona, Tucson 85721.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
|
