Source:http://linkedlifedata.com/resource/pubmed/id/20140742
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
9
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pubmed:dateCreated |
2010-7-23
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pubmed:abstractText |
The leukemias account for the largest number of cases of childhood cancer and remain the primary cause of cancer-related mortality among children in the United States. There is a need for novel antileukemia agents due to toxicity and resistant to existing chemotherapeutic agents. In this study, the effects of pseudolaric acid B (PAB) on three human leukemia cell lines, acute promyelocytic leukemia HL-60 cells, acute lymphoblastic leukemia CCRF-CEM cells, and human chronic myeloid leukemia blast-phase K562 cells were investigated in vitro, compared to normal human peripheral blood mononuclear cells (PBMC).
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1432-1335
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
136
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1333-40
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pubmed:meshHeading |
pubmed-meshheading:20140742-Apoptosis,
pubmed-meshheading:20140742-Cell Cycle,
pubmed-meshheading:20140742-Cell Line, Tumor,
pubmed-meshheading:20140742-Cell Proliferation,
pubmed-meshheading:20140742-Cell Survival,
pubmed-meshheading:20140742-Diterpenes,
pubmed-meshheading:20140742-Dose-Response Relationship, Drug,
pubmed-meshheading:20140742-Drug Screening Assays, Antitumor,
pubmed-meshheading:20140742-HL-60 Cells,
pubmed-meshheading:20140742-Humans,
pubmed-meshheading:20140742-K562 Cells,
pubmed-meshheading:20140742-Leukemia,
pubmed-meshheading:20140742-Pinaceae,
pubmed-meshheading:20140742-Structure-Activity Relationship
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pubmed:year |
2010
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pubmed:articleTitle |
Selective inhibition of human leukemia cell growth and induction of cell cycle arrest and apoptosis by pseudolaric acid B.
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pubmed:affiliation |
The National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.
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