Linked Life Data

2014068

Source:http://linkedlifedata.com/resource/pubmed/id/2014068

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1991-5-10
pubmed:abstractText
Haloperidol and pimozide are the only medications approved in management of Tourette's syndrome, thought due to dopaminergic overactivity with a possible genetic trait. The effect of equal dose regimens of these drugs on some brain biogenic amines and major acidic metabolites was studied in two genetically different strains of mice. These drugs exerted strain-dependent effect on regional brain levels of the compounds measured. The results suggest a higher turnover of striatal dopamine by haloperidol than by pimozide in the albino BALB/c but not in the black C57BL/6 mouse strain which may explain the high incidences of haloperidol-induced extrapyramidal side effects. Conversely, a greater decrease in serotonin turnover by pimozide than by haloperidol was apparent in two brain regions of C57BL/6 but not in BALB/c mice which may contribute to the unwanted sedative effect reported for pimozide. The results suggest the possible contribution of genetic factors to cerebral potency of these neuroleptics which may explain variable therapeutic response and sensitivity to drug-produced toxicity in Tourette's syndrome.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0161-813X
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
47-54
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Genetics, haloperidol and pimozide: a comparative study in two mouse strains.
pubmed:affiliation
Department of Pharmacology, University of North Dakota School of Medicine, Grand Forks 58203.
pubmed:publicationType
Journal Article, Comparative Study