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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2010-2-22
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pubmed:abstractText |
A series of novel benzoxazole derivatives has been designed and shown to exhibit attractive JAK2 inhibitory profiles in biochemical and cellular assays, capable of delivering compounds with favorable PK properties in rats. Synthesis and structure-activity relationship data are also provided.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1464-3405
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pubmed:author |
pubmed-author:AichholzReinerR,
pubmed-author:BaffertFabienneF,
pubmed-author:BlascoFrancescaF,
pubmed-author:BuhlThomasT,
pubmed-author:ChenePatrickP,
pubmed-author:De PoverAlainA,
pubmed-author:DrueckesPeterP,
pubmed-author:EndresRalfR,
pubmed-author:ErdmannDirkD,
pubmed-author:FuretPascalP,
pubmed-author:GaulChristophC,
pubmed-author:GerspacherMarcM,
pubmed-author:HofmannFrancescoF,
pubmed-author:HolzerPhilippP,
pubmed-author:LangMarcM,
pubmed-author:Pissot-SoldermannCaroleC,
pubmed-author:RadimerskiThomasT,
pubmed-author:RegnierCatherine HCH,
pubmed-author:TrappeJörgJ,
pubmed-author:VangrevelingheEricE
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pubmed:copyrightInfo |
Copyright 2010 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
20
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
1724-7
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pubmed:meshHeading |
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pubmed:year |
2010
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pubmed:articleTitle |
2-Amino-aryl-7-aryl-benzoxazoles as potent, selective and orally available JAK2 inhibitors.
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pubmed:affiliation |
Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH-4002 Basel, Switzerland. marc.gerspacher@novartis.com
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pubmed:publicationType |
Journal Article
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