| pubmed-article:20137987 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20137987 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:20137987 | lifeskim:mentions | umls-concept:C0024518 | lld:lifeskim |
| pubmed-article:20137987 | lifeskim:mentions | umls-concept:C0040223 | lld:lifeskim |
| pubmed-article:20137987 | lifeskim:mentions | umls-concept:C0439857 | lld:lifeskim |
| pubmed-article:20137987 | lifeskim:mentions | umls-concept:C0678894 | lld:lifeskim |
| pubmed-article:20137987 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:20137987 | pubmed:dateCreated | 2010-3-1 | lld:pubmed |
| pubmed-article:20137987 | pubmed:abstractText | T cell receptor (TCR) binding to diverse peptide-major histocompatibility complex (pMHC) ligands results in various degrees of T cell activation. Here we analyze which binding properties of the TCR-pMHC interaction are responsible for this variation in pMHC activation potency. We have analyzed activation of the 1G4 cytotoxic T lymphocyte clone by cognate pMHC variants and performed thorough correlation analysis of T cell activation with 1G4 TCR-pMHC binding properties measured in solution. We found that both the on rate (k(on)) and off rate (k(off)) contribute to activation potency. Based on our results, we propose a model in which rapid TCR rebinding to the same pMHC after chemical dissociation increases the effective half-life or "confinement time" of a TCR-pMHC interaction. This confinement time model clarifies the role of k(on) in T cell activation and reconciles apparently contradictory reports on the role of TCR-pMHC binding kinetics and affinity in T cell activation. | lld:pubmed |
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| pubmed-article:20137987 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20137987 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20137987 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20137987 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20137987 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:20137987 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20137987 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:20137987 | pubmed:issn | 1097-4180 | lld:pubmed |
| pubmed-article:20137987 | pubmed:author | pubmed-author:ZhangHaoH | lld:pubmed |
| pubmed-article:20137987 | pubmed:author | pubmed-author:van der... | lld:pubmed |
| pubmed-article:20137987 | pubmed:author | pubmed-author:CerundoloVinc... | lld:pubmed |
| pubmed-article:20137987 | pubmed:author | pubmed-author:ChenJi-LiJL | lld:pubmed |
| pubmed-article:20137987 | pubmed:author | pubmed-author:CoombsDanielD | lld:pubmed |
| pubmed-article:20137987 | pubmed:author | pubmed-author:AleksicMilosM | lld:pubmed |
| pubmed-article:20137987 | pubmed:author | pubmed-author:DushekOmerO | lld:pubmed |
| pubmed-article:20137987 | pubmed:author | pubmed-author:ShenderovEuge... | lld:pubmed |
| pubmed-article:20137987 | pubmed:copyrightInfo | Copyright 2010 Elsevier Inc. All rights reserved. | lld:pubmed |
| pubmed-article:20137987 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20137987 | pubmed:day | 26 | lld:pubmed |
| pubmed-article:20137987 | pubmed:volume | 32 | lld:pubmed |
| pubmed-article:20137987 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20137987 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20137987 | pubmed:pagination | 163-74 | lld:pubmed |
| pubmed-article:20137987 | pubmed:dateRevised | 2010-9-27 | lld:pubmed |
| pubmed-article:20137987 | pubmed:meshHeading | pubmed-meshheading:20137987... | lld:pubmed |
| pubmed-article:20137987 | pubmed:meshHeading | pubmed-meshheading:20137987... | lld:pubmed |
| pubmed-article:20137987 | pubmed:meshHeading | pubmed-meshheading:20137987... | lld:pubmed |
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| pubmed-article:20137987 | pubmed:meshHeading | pubmed-meshheading:20137987... | lld:pubmed |
| pubmed-article:20137987 | pubmed:meshHeading | pubmed-meshheading:20137987... | lld:pubmed |
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| pubmed-article:20137987 | pubmed:meshHeading | pubmed-meshheading:20137987... | lld:pubmed |
| pubmed-article:20137987 | pubmed:meshHeading | pubmed-meshheading:20137987... | lld:pubmed |
| pubmed-article:20137987 | pubmed:meshHeading | pubmed-meshheading:20137987... | lld:pubmed |
| pubmed-article:20137987 | pubmed:meshHeading | pubmed-meshheading:20137987... | lld:pubmed |
| pubmed-article:20137987 | pubmed:meshHeading | pubmed-meshheading:20137987... | lld:pubmed |
| pubmed-article:20137987 | pubmed:meshHeading | pubmed-meshheading:20137987... | lld:pubmed |
| pubmed-article:20137987 | pubmed:meshHeading | pubmed-meshheading:20137987... | lld:pubmed |
| pubmed-article:20137987 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20137987 | pubmed:articleTitle | Dependence of T cell antigen recognition on T cell receptor-peptide MHC confinement time. | lld:pubmed |
| pubmed-article:20137987 | pubmed:affiliation | Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK. | lld:pubmed |
| pubmed-article:20137987 | pubmed:publicationType | Journal Article | lld:pubmed |
