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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2010-3-1
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pubmed:abstractText |
T cell receptor (TCR) binding to diverse peptide-major histocompatibility complex (pMHC) ligands results in various degrees of T cell activation. Here we analyze which binding properties of the TCR-pMHC interaction are responsible for this variation in pMHC activation potency. We have analyzed activation of the 1G4 cytotoxic T lymphocyte clone by cognate pMHC variants and performed thorough correlation analysis of T cell activation with 1G4 TCR-pMHC binding properties measured in solution. We found that both the on rate (k(on)) and off rate (k(off)) contribute to activation potency. Based on our results, we propose a model in which rapid TCR rebinding to the same pMHC after chemical dissociation increases the effective half-life or "confinement time" of a TCR-pMHC interaction. This confinement time model clarifies the role of k(on) in T cell activation and reconciles apparently contradictory reports on the role of TCR-pMHC binding kinetics and affinity in T cell activation.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20137987-10358766,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20137987-10398592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20137987-10878370,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20137987-10940241,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20137987-11224522,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20137987-11238586,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20137987-11249650,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20137987-11397806,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20137987-11420037,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20137987-12594952,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20137987-14690592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20137987-15004033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20137987-15772168,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20137987-15837811,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20137987-15916940,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20137987-16537380,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20137987-16932807,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20137987-17295390,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20137987-17313485,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20137987-17367335,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20137987-17560121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20137987-17709510,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20137987-17984179,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20137987-18227132,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20137987-1829108,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20137987-18390627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20137987-18579518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20137987-19464197,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20137987-19553539,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20137987-19956745,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20137987-20189475,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20137987-2342577,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20137987-7139033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20137987-7541822,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20137987-7761445,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20137987-8606766,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20137987-8871350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20137987-9050879,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20137987-9432985,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20137987-95173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20137987-9670927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20137987-9820494,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20137987-9881972
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1097-4180
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2010 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
26
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pubmed:volume |
32
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
163-74
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pubmed:dateRevised |
2010-9-27
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pubmed:meshHeading |
pubmed-meshheading:20137987-Clone Cells,
pubmed-meshheading:20137987-Cytotoxicity, Immunologic,
pubmed-meshheading:20137987-HLA-A2 Antigen,
pubmed-meshheading:20137987-Humans,
pubmed-meshheading:20137987-Interferon-gamma,
pubmed-meshheading:20137987-Lymphocyte Activation,
pubmed-meshheading:20137987-Models, Immunological,
pubmed-meshheading:20137987-Neoplasm Proteins,
pubmed-meshheading:20137987-Peptide Fragments,
pubmed-meshheading:20137987-Protein Binding,
pubmed-meshheading:20137987-Receptors, Antigen, T-Cell,
pubmed-meshheading:20137987-Surface Plasmon Resonance,
pubmed-meshheading:20137987-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:20137987-Time Factors,
pubmed-meshheading:20137987-Transfection
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pubmed:year |
2010
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pubmed:articleTitle |
Dependence of T cell antigen recognition on T cell receptor-peptide MHC confinement time.
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pubmed:affiliation |
Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.
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pubmed:publicationType |
Journal Article
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