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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11-12
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pubmed:dateCreated |
2010-10-18
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pubmed:abstractText |
Increased oxidative stress plays an important role in cardiovascular diseases including hypertension and stroke. Evidence has indicated that ketone bodies could exert antioxidative effects. We explored the role of renal mitochondrial 3-hydroxy-3-methylglutaryl-coenzyme A synthase (HMGCS2) expression, a key control site of ketogenesis, in stroke-prone spontaneously hypertensive rats (SHRSPs) and their ancestral hypertensive but stroke-resistant spontaneously hypertensive rats (SHRs).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1873-1244
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2010 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1176-80
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pubmed:meshHeading |
pubmed-meshheading:20137896-Animals,
pubmed-meshheading:20137896-Antihypertensive Agents,
pubmed-meshheading:20137896-Catalase,
pubmed-meshheading:20137896-Clofibrate,
pubmed-meshheading:20137896-Down-Regulation,
pubmed-meshheading:20137896-Hydroxymethylglutaryl-CoA Synthase,
pubmed-meshheading:20137896-Hypertension,
pubmed-meshheading:20137896-Kidney,
pubmed-meshheading:20137896-Male,
pubmed-meshheading:20137896-Malondialdehyde,
pubmed-meshheading:20137896-Mitochondria,
pubmed-meshheading:20137896-Oxidative Stress,
pubmed-meshheading:20137896-PPAR gamma,
pubmed-meshheading:20137896-Phosphorylation,
pubmed-meshheading:20137896-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:20137896-Rats,
pubmed-meshheading:20137896-Rats, Inbred SHR,
pubmed-meshheading:20137896-Stroke,
pubmed-meshheading:20137896-Up-Regulation
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pubmed:articleTitle |
Mitochondrial HMG-CoA synthase partially contributes to antioxidant protection in the kidney of stroke-prone spontaneously hypertensive rats.
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pubmed:affiliation |
Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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