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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2010-5-21
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pubmed:abstractText |
Minichromosome maintenance (MCM) proteins act as the origin licensing machinery that regulates initiation of DNA replication. Geminin is a licensing repressor and prevents reinitiation of DNA replication by blocking reloading of MCM proteins at replication origins. Recent studies have proposed that MCM7 and geminin may be sensitive proliferative and prognostic markers of various malignant tumors. This study aimed to analyze the expression of MCM7 and geminin to clarify pathobiological significance in human oral squamous cell carcinomas (OSCCs).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
D
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1600-0714
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
39
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
328-34
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pubmed:meshHeading |
pubmed-meshheading:20136698-Aged,
pubmed-meshheading:20136698-Carcinoma, Squamous Cell,
pubmed-meshheading:20136698-Carcinoma in Situ,
pubmed-meshheading:20136698-Cell Cycle Proteins,
pubmed-meshheading:20136698-Cell Line, Tumor,
pubmed-meshheading:20136698-Chemotherapy, Adjuvant,
pubmed-meshheading:20136698-DNA Replication,
pubmed-meshheading:20136698-DNA-Binding Proteins,
pubmed-meshheading:20136698-Epithelium,
pubmed-meshheading:20136698-Female,
pubmed-meshheading:20136698-Humans,
pubmed-meshheading:20136698-Immunohistochemistry,
pubmed-meshheading:20136698-Lymphatic Metastasis,
pubmed-meshheading:20136698-Male,
pubmed-meshheading:20136698-Mouth Mucosa,
pubmed-meshheading:20136698-Mouth Neoplasms,
pubmed-meshheading:20136698-Neoadjuvant Therapy,
pubmed-meshheading:20136698-Neoplasm Staging,
pubmed-meshheading:20136698-Nuclear Proteins,
pubmed-meshheading:20136698-Precancerous Conditions,
pubmed-meshheading:20136698-Prognosis,
pubmed-meshheading:20136698-Radiotherapy, Adjuvant,
pubmed-meshheading:20136698-Survival Rate,
pubmed-meshheading:20136698-Tumor Markers, Biological
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pubmed:year |
2010
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pubmed:articleTitle |
Minichromosome maintenance-7 and geminin are reliable prognostic markers in patients with oral squamous cell carcinoma: immunohistochemical study.
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pubmed:affiliation |
Division of Organ Pathology, Department of Microbiology and Pathology, Faculty of Medicine, Tottori University, Yonago, Japan. tamura26@med.tottori-u.ac.jp
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pubmed:publicationType |
Journal Article,
Comparative Study
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