Source:http://linkedlifedata.com/resource/pubmed/id/20136432
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2010-2-8
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| pubmed:abstractText |
Edible mushrooms contain an abundance of immune-enhancing nutritients. Some of these compounds, referred to as biological response modifiers (BRMs), have been used in biological therapies for cancer treatment. We obtained a low-molecular-weight protein fraction (MLP-Fraction) from the fruiting body of the maitake mushroom Grifola frondosa by multiple sequential steps, including ethanol precipitation, DEAE-exchange chromatography, and gel filtration. The effect of the MLP-Fraction on the immune system was determined using normal mice. This resulted in a simultaneous increase in splenocyte proliferation and production of cytokines such as interleukin (IL)-1alpha, tumor necrosis factor-alpha, IL-10, IL-12, and interferon (IFN)-gamma. The expression levels of IFN-gamma and IL-12 in antigen-presenting cells (APCs) and the activation of natural killer (NK) cells, macrophages, and dendritic cells were observed. These results suggest a mechanism in which NK cells are activated through cytokines produced by APCs. We also confirmed the possibility that the MLP-Fraction acts as a BRM using colon-26 carcinoma-bearing mice. This fraction enhanced the production of IL-12 and IFN-gamma by splenocytes in tumor-bearing mice and clearly showed an inhibitory effect on tumor cell growth.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Feb
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| pubmed:issn |
1557-7600
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
13
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
20-30
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| pubmed:meshHeading |
pubmed-meshheading:20136432-Animals,
pubmed-meshheading:20136432-Antigen-Presenting Cells,
pubmed-meshheading:20136432-Antineoplastic Agents,
pubmed-meshheading:20136432-Carcinoma,
pubmed-meshheading:20136432-Colonic Neoplasms,
pubmed-meshheading:20136432-Cytokines,
pubmed-meshheading:20136432-Dendritic Cells,
pubmed-meshheading:20136432-Female,
pubmed-meshheading:20136432-Fruiting Bodies, Fungal,
pubmed-meshheading:20136432-Fungal Proteins,
pubmed-meshheading:20136432-Grifola,
pubmed-meshheading:20136432-Immunologic Factors,
pubmed-meshheading:20136432-Killer Cells, Natural,
pubmed-meshheading:20136432-Macrophages,
pubmed-meshheading:20136432-Mice,
pubmed-meshheading:20136432-Mice, Inbred BALB C,
pubmed-meshheading:20136432-Reference Values,
pubmed-meshheading:20136432-Spleen
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| pubmed:year |
2010
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| pubmed:articleTitle |
Potential antitumor activity of a low-molecular-weight protein fraction from Grifola frondosa through enhancement of cytokine production.
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| pubmed:affiliation |
Laboratory of Molecular Pharmacology, Biosignal Research Center, Kobe University, Higashinada-ku, Kobe, Japan. kodaman@kobepharma-u.ac.jp
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| pubmed:publicationType |
Journal Article
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