20136427

Source:http://linkedlifedata.com/resource/pubmed/id/20136427

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0021368, umls-concept:C0026336, umls-concept:C0079189, umls-concept:C0301625, umls-concept:C0314719, umls-concept:C0333348, umls-concept:C0964609, umls-concept:C1299003, umls-concept:C1517004, umls-concept:C1518102, umls-concept:C1527144, umls-concept:C1879547
pubmed:issue	2
pubmed:dateCreated	2010-2-8
pubmed:abstractText	To investigate the effect of DA-6034, 7-carboxymethyloxy-3',4',5-trimethoxy flavone, in experimentally-induced inflammatory dry eye in rabbit. In addition, to elucidate the mechanism of DA-6034, we evaluated the mitogen-activated protein kinase (MAPK) signaling pathway and transcriptional factor-kappa B (NF-kB) in corneal epithelial cells.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/8104312
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/7-carboxymethoxyloxy-3',4',5-trimeth..., http://linkedlifedata.com/resource/pubmed/chemical/Cytokines, http://linkedlifedata.com/resource/pubmed/chemical/Flavonoids, http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 9, http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases, http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B
pubmed:status	MEDLINE
pubmed:month	Feb
pubmed:issn	1460-2202
pubmed:author	pubmed-author:KangKyung KooKK, pubmed-author:KimJu MiJM, pubmed-author:LeeMin JungMJ, pubmed-author:SeoMi JeongMJ, pubmed-author:SohnYong SungYS, pubmed-author:YooMoohiM
pubmed:issnType	Electronic
pubmed:volume	35
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	165-75
pubmed:meshHeading	pubmed-meshheading:20136427-Administration, Topical, pubmed-meshheading:20136427-Animals, pubmed-meshheading:20136427-Blotting, Western, pubmed-meshheading:20136427-Cell Culture Techniques, pubmed-meshheading:20136427-Cytokines, pubmed-meshheading:20136427-Dacryocystitis, pubmed-meshheading:20136427-Disease Models, Animal, pubmed-meshheading:20136427-Dry Eye Syndromes, pubmed-meshheading:20136427-Enzyme Activation, pubmed-meshheading:20136427-Enzyme-Linked Immunosorbent Assay, pubmed-meshheading:20136427-Epithelium, Corneal, pubmed-meshheading:20136427-Flavonoids, pubmed-meshheading:20136427-MAP Kinase Signaling System, pubmed-meshheading:20136427-Matrix Metalloproteinase 9, pubmed-meshheading:20136427-Mitogen-Activated Protein Kinases, pubmed-meshheading:20136427-NF-kappa B, pubmed-meshheading:20136427-Phosphorylation, pubmed-meshheading:20136427-Rabbits, pubmed-meshheading:20136427-Tears
pubmed:year	2010
pubmed:articleTitle	The therapeutic effect of DA-6034 on ocular inflammation via suppression of MMP-9 and inflammatory cytokines and activation of the MAPK signaling pathway in an experimental dry eye model.
pubmed:affiliation	Research Institutes, Dong-A Pharmaceutical Company, Yongin, Kyunggi, South Korea.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't