Linked Life Data

20135347

Source:http://linkedlifedata.com/resource/pubmed/id/20135347

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2010-3-16
pubmed:abstractText
Triple-negative breast cancer (TNB) has poor prognosis and moreover patients with TNB do not benefit from established targeted drugs with endocrine therapy or trastuzumab. The aim of the study was to analyze the prevalence of candidate biomarkers in tumors from patients with TNB. Tissue microarrays were prepared from primary tumors from premenopausal breast cancer patients (500/564) randomized to adjuvant tamoxifen or no adjuvant treatment. Immunohistochemical (IHC) staining included ER, PR, HER2, epidermal receptor growth factor (EGFR), vascular endothelial growth factor A (VEGF-A), and vascular endothelial growth factor receptor 2 (VEGFR2). EGFR and HER2 gene copy number was defined by fluorescence in situ hybridization (FISH). All patients were included in the descriptive analysis, but only untreated patients in the survival analysis. TNB was diagnosed in 96 patients and correlated significantly to low age, Nottingham histological grade (NHG) III, high Ki67-index, T2 tumors, node negativity, EGFR positivity, increased EGFR gene copy number and high VEGFR2 expression. TNB was an independent prognostic factor for decreased 5-year breast cancer specific survival (BCSS) (HR 2.0 (95% CI 1.1-3.6), P = 0.01), but not for 10-year BCSS. High VEGFR2 expression was significantly correlated to decreased BCSS in TNB patients. TNB was associated with decreased BCSS and clinicopathological characteristics of an aggressive tumor type. High VEGFR2 expression, EGFR expression, and EGFR gene copy number were significantly correlated to TNB, supporting their role as putative candidate biomarkers for selection of targeted therapy in TNB.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1573-7217
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
120
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
491-8
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:20135347-Adult, pubmed-meshheading:20135347-Antineoplastic Agents, Hormonal, pubmed-meshheading:20135347-Breast Neoplasms, pubmed-meshheading:20135347-Chemotherapy, Adjuvant, pubmed-meshheading:20135347-Female, pubmed-meshheading:20135347-Follow-Up Studies, pubmed-meshheading:20135347-Gene Dosage, pubmed-meshheading:20135347-Humans, pubmed-meshheading:20135347-Immunohistochemistry, pubmed-meshheading:20135347-In Situ Hybridization, Fluorescence, pubmed-meshheading:20135347-Kaplan-Meier Estimate, pubmed-meshheading:20135347-Middle Aged, pubmed-meshheading:20135347-Neoplasm Staging, pubmed-meshheading:20135347-Receptor, Epidermal Growth Factor, pubmed-meshheading:20135347-Receptor, erbB-2, pubmed-meshheading:20135347-Receptors, Estrogen, pubmed-meshheading:20135347-Receptors, Progesterone, pubmed-meshheading:20135347-Tamoxifen, pubmed-meshheading:20135347-Tissue Array Analysis, pubmed-meshheading:20135347-Tumor Markers, Biological, pubmed-meshheading:20135347-Vascular Endothelial Growth Factor Receptor-2
pubmed:year
2010
pubmed:articleTitle
Epidermal growth factor receptor and vascular endothelial growth factor receptor 2 are specific biomarkers in triple-negative breast cancer. Results from a controlled randomized trial with long-term follow-up.
pubmed:affiliation
Department of Surgery, Institution of Clinical Sciences, Lund University Hospital, SE 221 85, Lund, Sweden. Lisa.Ryden@med.lu.se
pubmed:publicationType
Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, Multicenter Study