Source:http://linkedlifedata.com/resource/pubmed/id/20134415
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
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| pubmed:dateCreated |
2010-9-27
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| pubmed:abstractText |
Aims of the study were to measure insulin-like growth factor-binding protein-2 (IGFBP-2) expression by abdominal subcutaneous adipocytes and to assess the relationship between IGFBP-2 expression, circulating IGFBP-2, obesity, and insulin sensitivity in obese children. Thirty-eight obese children were recruited. Insulin sensitivity was assessed by intravenous glucose tolerance test and body composition by total-body dual-energy X-ray absorptiometry. Serum free and total IGF-I, IGFBP-2, adiponectin, and leptin were measured. Relative quantification of IGFBP-2 mRNA by subcutaneous adipose tissue biopsies was obtained using real-time PCR. Circulating IGFBP-2 was positively associated with insulin sensitivity, in agreement with previous studies. IGFBP-2 expression was associated with fat mass percentage (r = 0.656; P < 0.02), insulin sensitivity (r = -0.604; P < 0.05), free IGF-I (r = 0.646; P < 0.05), and leptin (r = 0.603; P < 0.05), but not with circulating IGFBP-2 (r = 0.003, P = ns). The association between IGFBP-2 expression and adiposity (r = 0.648; P < 0.05) was independent of insulin sensitivity (covariate). In conclusion, circulating IGFBP-2 was positively associated with insulin sensitivity. IGFBP-2 was expressed by subcutaneous abdominal adipocytes of obese children and increased with adiposity, independently from the level of insulin sensitivity. IGFBP-2 expression may potentially be one of the local mechanisms used by adipocytes to limit further fat gain.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Oct
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| pubmed:issn |
1930-7381
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
18
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
2055-7
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| pubmed:meshHeading |
pubmed-meshheading:20134415-Adipocytes,
pubmed-meshheading:20134415-Child,
pubmed-meshheading:20134415-Female,
pubmed-meshheading:20134415-Humans,
pubmed-meshheading:20134415-Insulin Resistance,
pubmed-meshheading:20134415-Insulin-Like Growth Factor Binding Protein 2,
pubmed-meshheading:20134415-Insulin-Like Growth Factor I,
pubmed-meshheading:20134415-Leptin,
pubmed-meshheading:20134415-Male,
pubmed-meshheading:20134415-Obesity,
pubmed-meshheading:20134415-Subcutaneous Fat
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| pubmed:year |
2010
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| pubmed:articleTitle |
Adipocytes IGFBP-2 expression in prepubertal obese children.
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| pubmed:affiliation |
Regional Centre for Juvenile Diabetes, Section of Obesity and Clinical Nutrition, Department of Mother and Child, Biology-Genetics, University of Verona, Verona, Italy. claudio.maffeis@univr.it
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| pubmed:publicationType |
Journal Article
|