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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2010-3-15
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pubmed:abstractText |
Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are severe, bullous cutaneous diseases with uncertain pathogenesis, although cytotoxic T cells seem to be involved. Natural killer (NK)-like activity has been found in blister infiltrates. Cytotoxic T lymphocytes (CTLs) with NK-like activity (NK-CTLs) have been shown to express T-cell receptors restricted by the HLA-Ib molecule HLA-E. Alternatively, the HLA-E-specific activating receptor CD94/NKG2C can trigger T-cell receptor-independent cytotoxicity in CTLs.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1097-6825
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
125
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
703-10, 710.e1-710.e8
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pubmed:meshHeading |
pubmed-meshheading:20132973-Blotting, Western,
pubmed-meshheading:20132973-Cell Line,
pubmed-meshheading:20132973-Cell Separation,
pubmed-meshheading:20132973-Epidermal Necrolysis, Toxic,
pubmed-meshheading:20132973-Flow Cytometry,
pubmed-meshheading:20132973-HLA Antigens,
pubmed-meshheading:20132973-Histocompatibility Antigens Class I,
pubmed-meshheading:20132973-Humans,
pubmed-meshheading:20132973-Immunohistochemistry,
pubmed-meshheading:20132973-Keratinocytes,
pubmed-meshheading:20132973-Lymphocyte Activation,
pubmed-meshheading:20132973-NK Cell Lectin-Like Receptor Subfamily C,
pubmed-meshheading:20132973-NK Cell Lectin-Like Receptor Subfamily D,
pubmed-meshheading:20132973-Natural Killer T-Cells,
pubmed-meshheading:20132973-Stevens-Johnson Syndrome
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pubmed:year |
2010
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pubmed:articleTitle |
CD94/NKG2C is a killer effector molecule in patients with Stevens-Johnson syndrome and toxic epidermal necrolysis.
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pubmed:affiliation |
Research Unit, Hospital Universitario La Paz-FIBHULP, Madrid, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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