Source:http://linkedlifedata.com/resource/pubmed/id/20132301
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2010-6-29
|
| pubmed:abstractText |
Primary central nervous system lymphoma (PCNSL) related to acquired immunodeficiency syndrome (AIDS) is a lethal disorder, but the recent application of highly active antiretroviral therapy (HAART) has significantly improved prognosis. This retrospective cohort study of AIDS-related PCNSL examined the actual clinical outcomes and prognostic variables affecting overall survival (OS) in the HAART era. Twenty-three newly diagnosed AIDS-related PCNSL at 12 regional centre hospitals for HIV/AIDS in Japan between 2002 and 2008 were consecutively enrolled. The estimated 3-yr OS rate of the entire cohort was 64% (95%CI, 41.0-80.3%). Whole brain radiation therapy (WBRT) had an independent positive impact on survival (WBRT >or=30 Gy vs. others, P = 0.02). Nine of 10 patients with a good performance status (PS) (0-2) remained alive with complete response, whereas 10 (77%) of 13 of those with a poor PS (3-4) died mostly after a short period. The estimated 3-yr OS rate of the groups with a good and poor PS was 100% and 38% (95%CI, 14-63%), respectively (P = 0.01). Leukoencephalopathy (grade >or= 2) developed in 21% of those that survived more than 12 months after radiation. The patients receiving a curative intent radiation dose (>or=30 Gy) of WBRT achieved prolonged survival while maintaining a good quality of life in the HAART era, especially among patients with a favourable PS.
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| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
1600-0609
|
| pubmed:author |
pubmed-author:AjisawaAtsushiA,
pubmed-author:HagiwaraShotaroS,
pubmed-author:KambeToshiyukiT,
pubmed-author:KonishiMitsuruM,
pubmed-author:MiyakawaToshikazuT,
pubmed-author:NagaiHirokazuH,
pubmed-author:OdawaraTakashiT,
pubmed-author:OkadaSeijiS,
pubmed-author:SaitoSeijiS,
pubmed-author:TakahamaSoichiroS,
pubmed-author:TanumaJunkoJ,
pubmed-author:TateyamaMasaoM,
pubmed-author:UchiumiHidekiH,
pubmed-author:UehiraTomokoT,
pubmed-author:WatanabeAkiraA,
pubmed-author:WatanabeTomoyukiT,
pubmed-author:YotsumotoMihokoM
|
| pubmed:issnType |
Electronic
|
| pubmed:volume |
84
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
499-505
|
| pubmed:dateRevised |
2010-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:20132301-Adult,
pubmed-meshheading:20132301-Antiretroviral Therapy, Highly Active,
pubmed-meshheading:20132301-Brain Neoplasms,
pubmed-meshheading:20132301-Cohort Studies,
pubmed-meshheading:20132301-Female,
pubmed-meshheading:20132301-Humans,
pubmed-meshheading:20132301-Kaplan-Meier Estimate,
pubmed-meshheading:20132301-Leukoencephalopathies,
pubmed-meshheading:20132301-Lymphoma, AIDS-Related,
pubmed-meshheading:20132301-Male,
pubmed-meshheading:20132301-Middle Aged,
pubmed-meshheading:20132301-Prognosis,
pubmed-meshheading:20132301-Radiation Injuries,
pubmed-meshheading:20132301-Radiotherapy Dosage,
pubmed-meshheading:20132301-Remission Induction,
pubmed-meshheading:20132301-Retrospective Studies,
pubmed-meshheading:20132301-Treatment Outcome,
pubmed-meshheading:20132301-Young Adult
|
| pubmed:year |
2010
|
| pubmed:articleTitle |
Whole brain radiation alone produces favourable outcomes for AIDS-related primary central nervous system lymphoma in the HAART era.
|
| pubmed:affiliation |
Department of Hematology, National Hospital Organization Nagoya Medical Center, Nagoya, Japan. nagaih@nnh.hosp.go.jp
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|