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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2010-3-15
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pubmed:abstractText |
Selective serotonin reuptake inhibitors (SSRIs), in addition to their antidepressant effects, have been reported to have antiinflammatory effects. The aim of this study was to assess the antiarthritic potential of 2 SSRIs, fluoxetine and citalopram, in murine collagen-induced arthritis (CIA) and in a human ex vivo disease model of rheumatoid arthritis (RA).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1529-0131
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
62
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
683-93
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pubmed:meshHeading |
pubmed-meshheading:20131240-Animals,
pubmed-meshheading:20131240-Anti-Inflammatory Agents,
pubmed-meshheading:20131240-Arthritis, Experimental,
pubmed-meshheading:20131240-Arthritis, Rheumatoid,
pubmed-meshheading:20131240-Cells, Cultured,
pubmed-meshheading:20131240-Citalopram,
pubmed-meshheading:20131240-Cytokines,
pubmed-meshheading:20131240-Disease Models, Animal,
pubmed-meshheading:20131240-Disease Progression,
pubmed-meshheading:20131240-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:20131240-Fibroblasts,
pubmed-meshheading:20131240-Fluoxetine,
pubmed-meshheading:20131240-Humans,
pubmed-meshheading:20131240-Macrophages,
pubmed-meshheading:20131240-Male,
pubmed-meshheading:20131240-Mice,
pubmed-meshheading:20131240-Mice, Inbred DBA,
pubmed-meshheading:20131240-Serotonin Uptake Inhibitors,
pubmed-meshheading:20131240-Synovial Membrane,
pubmed-meshheading:20131240-Toll-Like Receptors
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pubmed:year |
2010
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pubmed:articleTitle |
Fluoxetine and citalopram exhibit potent antiinflammatory activity in human and murine models of rheumatoid arthritis and inhibit toll-like receptors.
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pubmed:affiliation |
Kennedy Institute of Rheumatology, Imperial College of Science, Technology, and Medicine, London, UK. s.sacre@bsms.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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