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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1991-5-16
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pubmed:abstractText |
The effects on motor behavior and forebrain dopamine (DA) synaptic function of withdrawal from chronic cocaine treatment were examined with simultaneous activity monitoring and microdialysis in nucleus accumbens. Rats exhibited behavioral sensitization to daily 30 mg/kg i.p. cocaine. After 18 days of daily cocaine and 7 days of withdrawal, dialysate DA and homovanillic acid (HVA) levels were reduced 36-38%, consistent with a synaptic DA deficiency.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0006-8993
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
11
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pubmed:volume |
538
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
337-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:2012975-Animals,
pubmed-meshheading:2012975-Brain Chemistry,
pubmed-meshheading:2012975-Cocaine,
pubmed-meshheading:2012975-Dialysis,
pubmed-meshheading:2012975-Dopamine,
pubmed-meshheading:2012975-Homovanillic Acid,
pubmed-meshheading:2012975-Male,
pubmed-meshheading:2012975-Motor Activity,
pubmed-meshheading:2012975-Nucleus Accumbens,
pubmed-meshheading:2012975-Rats,
pubmed-meshheading:2012975-Rats, Inbred Strains,
pubmed-meshheading:2012975-Substance Withdrawal Syndrome,
pubmed-meshheading:2012975-Synapses
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pubmed:year |
1991
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pubmed:articleTitle |
Apparent synaptic dopamine deficiency induced by withdrawal from chronic cocaine treatment.
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pubmed:affiliation |
Department of Behavioral Medicine, University of Virginia School of Medicine, Charlottesville 22908.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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