Linked Life Data

2012966

Source:http://linkedlifedata.com/resource/pubmed/id/2012966

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1991-5-16
pubmed:abstractText
Pontospinal noradrenergic neurons located in the A5, A7 and locus coeruleus/subcoeruleus (LC/SC) nuclei are the major source of the noradrenergic innervation of the spinal cord. However, the specific terminations of spinally-projecting noradrenergic neurons located in these nuclei have not been clearly defined. The purpose of the experiments described in this report was to more precisely define the spinal terminations of neurons located in the LC/SC using the anterograde tracer phaseolus vulgaris-leucoagglutinin in combination with dopamine-beta-hydroxylase (D beta H) immunocytochemistry. In addition, the spinal cord regions in which LC/SC neurons terminate was assessed by measuring the reduction in the density of D beta H-immunoreactive axon terminals in specific spinal cord regions after a unilateral electrolytic lesion that included LC/SC neurons. The results of these experiments indicate that the axons of LC neurons are located primarily in the ipsilateral ventral funiculus and terminate most heavily in the medial part of laminae VII and VIII, the motoneuron pool of lamina IX, and lamina X. LC neurons provide a moderately dense innervation of the ventral part of the dorsal horn, but only a very sparse innervation of the superficial dorsal horn. The SC projects ipsilaterally in the ventrolateral funiculus and terminates diffusely in the intermediate and ventral laminae of the spinal cord.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
11
pubmed:volume
538
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
231-45
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
The projection of locus coeruleus neurons to the spinal cord in the rat determined by anterograde tracing combined with immunocytochemistry.
pubmed:affiliation
University of Illinois, Chicago 60680.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.