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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2010-4-22
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pubmed:abstractText |
Intracerebroventricular injection of beta-amyloid(25-35) (Abeta(25-35)) in mice leads to cognitive deficits with the dysfunction of alpha7 nicotinic acetylcholine receptor (alpha7nAChR) within 1-2 weeks in a dose-dependent manner. The present study focused on the effect of DMXB, a selective alpha7nAChR agonist, on Abeta(25-35) (3 nmol)-impaired spatial memory and alpha7nAChR function. We found that the treatment with DMXB on days 1-10 after Abeta(25-35) injection dose-dependently prevented Abeta(25-35)-induced impairment of acquisition performance and probe trail test in Morris water maze. Importantly, the treatment with DMXB (1 mg/kg) perfectly prevented Abeta(25-35)-induced depression of alpha7nAChR response, which was associated with improving the probability of presynaptic glutamate release and the induction of high-frequency stimulation (HFS)-dependent long-term potentiation (LTP) in hippocampal Schaffer collaterale-CA1 synapse. Furthermore, although either the basal level of extracellular signal-regulated kinase 2 (ERK2) or its phosphorylation in the hippocampus had no difference between control and Abeta(25-35) mice, the Abeta(25-35) injection significantly attenuated HFS-triggered increase in ERK2 phosphorylation. The treatment with DMXB also rescued the ERK2 phosphorylation triggered by HFS in Abeta(25-35) mice that is required for LTP induction. This study firstly provides in vivo evidence that the anti-amnesic effect of DMXB is likely due to preventing the Abeta(25-35)-induced dysfunction of alpha7nAChR.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3-(2,4-dimethoxybenzylidene)anabasei...,
http://linkedlifedata.com/resource/pubmed/chemical/Amyloid beta-Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Benzylidene Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Nicotinic Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Pyridines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Nicotinic,
http://linkedlifedata.com/resource/pubmed/chemical/alpha7 nicotinic acetylcholine...,
http://linkedlifedata.com/resource/pubmed/chemical/amyloid beta-protein (25-35)
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1097-4547
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
88
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1784-94
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:20127813-Amyloid beta-Peptides,
pubmed-meshheading:20127813-Animals,
pubmed-meshheading:20127813-Behavior, Animal,
pubmed-meshheading:20127813-Benzylidene Compounds,
pubmed-meshheading:20127813-Cognition Disorders,
pubmed-meshheading:20127813-Disease Models, Animal,
pubmed-meshheading:20127813-Dose-Response Relationship, Drug,
pubmed-meshheading:20127813-Drug Interactions,
pubmed-meshheading:20127813-Electric Stimulation,
pubmed-meshheading:20127813-Evoked Potentials,
pubmed-meshheading:20127813-Gene Expression Regulation,
pubmed-meshheading:20127813-Hippocampus,
pubmed-meshheading:20127813-Male,
pubmed-meshheading:20127813-Maze Learning,
pubmed-meshheading:20127813-Mice,
pubmed-meshheading:20127813-Mice, Inbred ICR,
pubmed-meshheading:20127813-Mitogen-Activated Protein Kinase 1,
pubmed-meshheading:20127813-Neuronal Plasticity,
pubmed-meshheading:20127813-Nicotinic Agonists,
pubmed-meshheading:20127813-Peptide Fragments,
pubmed-meshheading:20127813-Phosphorylation,
pubmed-meshheading:20127813-Pyridines,
pubmed-meshheading:20127813-Reaction Time,
pubmed-meshheading:20127813-Receptors, Nicotinic,
pubmed-meshheading:20127813-Space Perception
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pubmed:year |
2010
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pubmed:articleTitle |
DMXB (GTS-21) ameliorates the cognitive deficits in beta amyloid(25-35(-) ) injected mice through preventing the dysfunction of alpha7 nicotinic receptor.
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pubmed:affiliation |
Department of Physiology, Nanjing Medical University, Nanjing, China.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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