Linked Life Data

20127253

Source:http://linkedlifedata.com/resource/pubmed/id/20127253

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2010-7-23
pubmed:abstractText
Abrogation of the function of TP53 gene is supposed to lead to a more aggressive breast cancer phenotype that produces a less favorable clinical outcome. The p21 gene on chromosome 6p21.2 can be stimulated by an activated TP53 gene. A product of transcription, the p21 protein, an inhibitor of cyclin-dependent kinases, has its function in gene repair and angiogenesis during cell division, and can regulate apoptosis. The purpose of this analysis was to examine for an association between the genotypes measured on two single nucleotide polymorphisms (SNPs) located within the TP53 and p21 genes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1432-1335
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
136
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1369-75
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
The role of TP53 and p21 gene polymorphisms in breast cancer biology in a well specified and characterized German cohort.
pubmed:affiliation
I Frauenklinik der Ludwig-Maximilians-Universität München, Maistrasse 11, 80337, Munich, Germany.
pubmed:publicationType
Journal Article