Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2010-2-3
pubmed:abstractText
Wnt signalling pathways have extremely diverse functions in animals, including induction of cell fates or tumours, guidance of cell movements during gastrulation, and the induction of cell polarity. Wnt can induce polar changes in cellular morphology by a remodelling of the cytoskeleton. However, how activation of the Frizzled receptor induces cytoskeleton rearrangement is not well understood. We show, by an in depth 4-D microscopy analysis, that the Caenorhabditis elegans Wnt pathway signals to CED-10/Rac via two separate branches to regulate modulation of the cytoskeleton in different cellular situations. Apoptotic cell clearance and migration of the distal tip cell require the MOM-5/Fz receptor, GSK-3 kinase, and APC/APR-1, which activate the CED-2/5/12 branch of the engulfment machinery. MOM-5 (Frizzled) thus can function as an engulfment receptor in C. elegans. Our epistatic analyses also suggest that the two partially redundant signalling pathways defined earlier for engulfment may act in a single pathway in early embryos. By contrast, rearrangement of mitotic spindles requires the MOM-5/Fz receptor, GSK-3 kinase, and beta-catenins, but not the downstream factors LIT-1/NLK or POP-1/Tcf. Taken together, our results indicate that in multiple developmental processes, CED-10/Rac can link polar signals mediated by the Wnt pathway to rearrangements of the cytoskeleton.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/20126385-10092617, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126385-10095101, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126385-10444600, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126385-10707082, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126385-11029006, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126385-11029007, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126385-11029008, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126385-11099033, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126385-11146658, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126385-11449279, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126385-11595183, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126385-11703939, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126385-12110172, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126385-12210516, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126385-12654300, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126385-14645848, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126385-15282167, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126385-15473839, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126385-15473860, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126385-15572126, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126385-15620652, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126385-15744306, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126385-16077004, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126385-16793760, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126385-16930586, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126385-17401362, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126385-17567952, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126385-18436785, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126385-18622031, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126385-1936965, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126385-3677169, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126385-4366476, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126385-7743934, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126385-7744956, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126385-8622870, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126385-8898226, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126385-9133433, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126385-9288749, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126385-9288750, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126385-9384382, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126385-9458047, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126385-9486639, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126385-9531567, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126385-9548255, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126385-9635425, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126385-9635426, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126385-9893023
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/CED-10 protein, C elegans, http://linkedlifedata.com/resource/pubmed/chemical/Caenorhabditis elegans Proteins, http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/High Mobility Group Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Mom-5 protein, C elegans, http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Wnt Proteins, http://linkedlifedata.com/resource/pubmed/chemical/beta Catenin, http://linkedlifedata.com/resource/pubmed/chemical/lit-1 protein, C elegans, http://linkedlifedata.com/resource/pubmed/chemical/pop-1 protein, C elegans, http://linkedlifedata.com/resource/pubmed/chemical/rac GTP-Binding Proteins
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1545-7885
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
e1000297
pubmed:dateRevised
2010-9-27
pubmed:meshHeading
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