20126327

Source:http://linkedlifedata.com/resource/pubmed/id/20126327

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0029944, umls-concept:C0178602, umls-concept:C0302350, umls-concept:C0879626, umls-concept:C1442989
pubmed:issue	3
pubmed:dateCreated	2010-2-3
pubmed:abstractText	A case of an acute dystonic reaction in a child presumptively treated for malaria with amodiaquine, and a case of persistent asymptomatic bradycardia in another child with mild pulmonary stenosis treated with a standard dose of amodiaquine for parasitologically confirmed uncomplicated malaria, is reported. Both subjects were homozygous for the wild type allele of cytochrome P450 2C8, the main enzyme responsible for amodiaquine metabolism. In both subjects, plasma concentrations of N-desethylamodiaquine and N-bis-desethylamodiaquine, the main metabolites of amodiaquine, were normal. No other drugs were detectable in the plasma of these two subjects after further toxicological screening. These observations, which suggest altered metabolism in the subject with an acute dystonic reaction, support the assertion that amodiaquine-associated dystonia is an idiosyncratic reaction. However, the occurrence of bradycardia after a standard dose of amodiaquine, which coincided with the time of expected peak concentrations of the active metabolite of amodiaquine, suggests a direct drug effect. These less reported adverse effects are likely to increase in parallel with the increased use of amodiaquine as a partner drug for combination therapy of malaria in Ghana. Further studies aimed at elucidating the mechanisms underlying these effects are, therefore, required.
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/20126327-11791962, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126327-11805197, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126327-12499196, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126327-14324229, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126327-15648312, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126327-15752375, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126327-15785959, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126327-1959977, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126327-2868340, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126327-3371193, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126327-3828191, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126327-4689836, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126327-5087836, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126327-5799189, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126327-9180596, http://linkedlifedata.com/resource/pubmed/commentcorrection/20126327-974497
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0073210
pubmed:status	PubMed-not-MEDLINE
pubmed:month	Sep
pubmed:issn	0016-9560
pubmed:author	pubmed-author:AdjeiG OGO, pubmed-author:AlifrangisMM, pubmed-author:GokaB QBQ, pubmed-author:HoegbergL C GLC, pubmed-author:KurtzhalsJalJ, pubmed-author:RodriguesO POP
pubmed:issnType	Print
pubmed:volume	43
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	135-8
pubmed:year	2009
pubmed:articleTitle	Amodiaquine-associated adverse effects after inadvertent overdose and after a standard therapeutic dose.
pubmed:affiliation	Centre for Tropical Clinical Pharmacology & Therapeutics, Accra, Ghana.
pubmed:publicationType	Journal Article