rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9-10
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pubmed:dateCreated |
2010-3-29
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pubmed:abstractText |
The analysis of amino acids (AA) and acylcarnitines (AC) by tandem mass spectrometry (MS/MS) is performed in newborn screening laboratories worldwide. While butyl esterification assays are routine, it is possible to detect AAs and ACs as their native free acids (underivatized). The Centers for Disease Control and Prevention's Newborn Screening Quality Assurance Program provides dried blood spot (DBS) quality control (QC) and proficiency testing (PT) programs for numerous MS/MS analytes. We describe empirical differences between derivatization and non-derivatization techniques for selected AAs and ACs.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amino Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Butanols,
http://linkedlifedata.com/resource/pubmed/chemical/Carnitine,
http://linkedlifedata.com/resource/pubmed/chemical/Leucine,
http://linkedlifedata.com/resource/pubmed/chemical/Methionine,
http://linkedlifedata.com/resource/pubmed/chemical/Palmitoylcarnitine,
http://linkedlifedata.com/resource/pubmed/chemical/Phenylalanine,
http://linkedlifedata.com/resource/pubmed/chemical/acylcarnitine,
http://linkedlifedata.com/resource/pubmed/chemical/glutarylcarnitine,
http://linkedlifedata.com/resource/pubmed/chemical/octanoylcarnitine,
http://linkedlifedata.com/resource/pubmed/chemical/propionylcarnitine
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1873-3492
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pubmed:author |
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pubmed:copyrightInfo |
Published by Elsevier B.V.
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pubmed:issnType |
Electronic
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pubmed:day |
2
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pubmed:volume |
411
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
684-9
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pubmed:meshHeading |
pubmed-meshheading:20122909-Amino Acids,
pubmed-meshheading:20122909-Butanols,
pubmed-meshheading:20122909-Carnitine,
pubmed-meshheading:20122909-Humans,
pubmed-meshheading:20122909-Infant, Newborn,
pubmed-meshheading:20122909-Leucine,
pubmed-meshheading:20122909-Metabolic Diseases,
pubmed-meshheading:20122909-Methionine,
pubmed-meshheading:20122909-Neonatal Screening,
pubmed-meshheading:20122909-Palmitoylcarnitine,
pubmed-meshheading:20122909-Phenylalanine,
pubmed-meshheading:20122909-Quality Control,
pubmed-meshheading:20122909-Tandem Mass Spectrometry
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pubmed:year |
2010
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pubmed:articleTitle |
Comparison of amino acids and acylcarnitines assay methods used in newborn screening assays by tandem mass spectrometry.
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pubmed:affiliation |
Newborn Screening Quality Assurance Program, Centers for Disease Control and Prevention, 4770 Buford Highway, NE, Mail Stop F-19, Atlanta, GA 30341, USA. vdejesus@cdc.gov
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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