Linked Life Data

2012256

Source:http://linkedlifedata.com/resource/pubmed/id/2012256

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1991-5-8
pubmed:abstractText
Various routes of Borrelia burgdorferi infection were studied in laboratory rats. Three-week-old Lewis rats were inoculated either intradermally (i.d.), intraperitoneally (i.p.), or oronasally (o.n.) with serial 10-fold dilutions of B. burgdorferi. Thirty days later, groups of rats were killed and serology, splenic culture, and histology were used to evaluate infection. Rats were successfully infected i.d. with 10(2-4) organisms or i.p. with 10(4-5) organisms. Neither three-day-old nor three-week-old rats were successfully infected o.n. with up to 10(6) organisms. For contact transmission, three-day-old or three-week-old inoculated rats were housed with unexposed littermates for 30 days. Inoculated rats became infected but contact rats remained free of infection. To study in utero transmission, five pregnant female Lewis rats were inoculated i.p. with 10(6) spirochetes at four days gestation. Although adult females seroconverted or had positive splenic cultures at 20 days gestation, the placentas and fetuses were uniformly culture-negative. Venereal transmission from seven infected females or six infected males to uninfected rats of the opposite sex was not demonstrated.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0002-9637
pubmed:author
pubmed:issnType
Print
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
135-9
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Relative infectivity of Borrelia burgdorferi in Lewis rats by various routes of inoculation.
pubmed:affiliation
Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.