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rdf:type |
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lifeskim:mentions |
umls-concept:C0001675,
umls-concept:C0010453,
umls-concept:C0010853,
umls-concept:C0028630,
umls-concept:C0205263,
umls-concept:C0242275,
umls-concept:C0591833,
umls-concept:C0600210,
umls-concept:C1113654,
umls-concept:C1511695,
umls-concept:C2348042
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pubmed:issue |
2
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pubmed:dateCreated |
2010-6-10
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pubmed:abstractText |
The adult subventricular zone (SVZ) contains neural stem cells that generate neuroblasts migrating to the olfactory bulb (OB) and differentiating into interneurones. The molecular cues controlling essential functions within the neurogenesis pathway such as proliferation, short and long distance migration, functional integration and cell survival are poorly understood. We have previously shown that cultured adult neural stem cells express a considerable variety of nucleotide receptors and that nucleotides and epidermal growth factor (EGF) induce converging intracellular signalling pathways that carry potential for synergism in the control of neural stem cell proliferation and cell survival. Here we investigate the role of EGF and the nucleotides ATP, ADPbetaS and UTP in neural stem cell migration.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine Diphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine Triphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Focal Adhesion Protein-Tyrosine...,
http://linkedlifedata.com/resource/pubmed/chemical/Nucleotides,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Purinergic P2,
http://linkedlifedata.com/resource/pubmed/chemical/Thionucleotides,
http://linkedlifedata.com/resource/pubmed/chemical/Uridine Triphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/adenosine 5'-O-(2-thiodiphosphate)
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1748-1716
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
199
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
181-9
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pubmed:meshHeading |
pubmed-meshheading:20121711-Adenosine Diphosphate,
pubmed-meshheading:20121711-Adenosine Triphosphate,
pubmed-meshheading:20121711-Animals,
pubmed-meshheading:20121711-Cell Movement,
pubmed-meshheading:20121711-Cells, Cultured,
pubmed-meshheading:20121711-Cytoskeleton,
pubmed-meshheading:20121711-Epidermal Growth Factor,
pubmed-meshheading:20121711-Focal Adhesion Protein-Tyrosine Kinases,
pubmed-meshheading:20121711-Mice,
pubmed-meshheading:20121711-Neurons,
pubmed-meshheading:20121711-Nucleotides,
pubmed-meshheading:20121711-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:20121711-Receptor, Epidermal Growth Factor,
pubmed-meshheading:20121711-Receptors, Purinergic P2,
pubmed-meshheading:20121711-Stem Cells,
pubmed-meshheading:20121711-Thionucleotides,
pubmed-meshheading:20121711-Uridine Triphosphate
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pubmed:year |
2010
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pubmed:articleTitle |
Nucleotides and epidermal growth factor induce parallel cytoskeletal rearrangements and migration in cultured adult murine neural stem cells.
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pubmed:affiliation |
Institute of Cell Biology and Neuroscience, Biocenter, Goethe-University, Frankfurt, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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