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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2010-2-19
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pubmed:databankReference |
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pubmed:abstractText |
On the basis of our understanding on the binding interactions of the benzothiophene template within the FIXa active site by X-ray crystallography and molecular modeling studies, we developed our SAR strategy by targeting the 4-position of the template to access the S1 beta and S2-S4 sites. A number of highly selective and potent factor Xa (FXa) and FIXa inhibitors were identified by simple switch of functional groups with conformational changes toward the S2-S4 sites.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1520-4804
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pubmed:author |
pubmed-author:AyeleTenagneT,
pubmed-author:BarryJohnJ,
pubmed-author:BaumgartnerChristineC,
pubmed-author:BeckRichardR,
pubmed-author:BlackneyMichaelM,
pubmed-author:BlenchTobyT,
pubmed-author:BurdAndrewA,
pubmed-author:BuxtonStuartS,
pubmed-author:ChahwalaSureshS,
pubmed-author:ChanderChamanC,
pubmed-author:CheungChimingC,
pubmed-author:DagostinClaudioC,
pubmed-author:GiddingsAmandaA,
pubmed-author:HolthoffHans-PeterHP,
pubmed-author:JoshiRinaR,
pubmed-author:MalicMajaM,
pubmed-author:MarlinFredericF,
pubmed-author:MurrayElizabethE,
pubmed-author:SajadMohammedM,
pubmed-author:ShaikhShahedaS,
pubmed-author:WangShoumingS
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pubmed:issnType |
Electronic
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pubmed:day |
25
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pubmed:volume |
53
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1473-82
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pubmed:meshHeading |
pubmed-meshheading:20121197-Animals,
pubmed-meshheading:20121197-Carbamates,
pubmed-meshheading:20121197-Crystallography, X-Ray,
pubmed-meshheading:20121197-Drug Design,
pubmed-meshheading:20121197-Factor IXa,
pubmed-meshheading:20121197-Hydrogen Bonding,
pubmed-meshheading:20121197-Models, Molecular,
pubmed-meshheading:20121197-Molecular Conformation,
pubmed-meshheading:20121197-Protein Binding,
pubmed-meshheading:20121197-Rats,
pubmed-meshheading:20121197-Rats, Sprague-Dawley,
pubmed-meshheading:20121197-Stereoisomerism,
pubmed-meshheading:20121197-Structure-Activity Relationship,
pubmed-meshheading:20121197-Thiophenes
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pubmed:year |
2010
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pubmed:articleTitle |
Structure based drug design: development of potent and selective factor IXa (FIXa) inhibitors.
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pubmed:affiliation |
Department of Medicinal Chemistry, Trigen Ltd., Emmanuel Kaye Building, 1B Manresa Road,London SW3 6LR, UK. shouming_wang@yahoo.co.uk
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pubmed:publicationType |
Journal Article
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