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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2010-10-18
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pubmed:abstractText |
The molecular mechanisms that underlie the methotrexate (MTX)-mediated disruption of intestinal barrier function have not been fully characterized. Epithelial barrier function is determined in large part by a multiprotein complex located at the most apical part of the lateral membrane, which is referred to as a tight junction (TJ). In the present study, we examined the alteration of zonula occludens-1 (ZO-1), which is a scaffolding protein that plays a pivotal role in the formation of TJs, to identify an additional molecular mechanism for epithelial barrier dysfunction.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antimetabolites, Antineoplastic,
http://linkedlifedata.com/resource/pubmed/chemical/Dextrans,
http://linkedlifedata.com/resource/pubmed/chemical/Fluorescein-5-isothiocyanate,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Methotrexate,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Reactive Oxygen Species,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine,
http://linkedlifedata.com/resource/pubmed/chemical/fluorescein isothiocyanate dextran,
http://linkedlifedata.com/resource/pubmed/chemical/zonula occludens-1 protein
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1432-0843
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
66
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1031-8
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pubmed:meshHeading |
pubmed-meshheading:20119715-Animals,
pubmed-meshheading:20119715-Antimetabolites, Antineoplastic,
pubmed-meshheading:20119715-Blotting, Western,
pubmed-meshheading:20119715-Dextrans,
pubmed-meshheading:20119715-Fluorescein-5-isothiocyanate,
pubmed-meshheading:20119715-Immunohistochemistry,
pubmed-meshheading:20119715-Immunoprecipitation,
pubmed-meshheading:20119715-Inflammation,
pubmed-meshheading:20119715-Intestinal Mucosa,
pubmed-meshheading:20119715-Intestine, Small,
pubmed-meshheading:20119715-Luminescence,
pubmed-meshheading:20119715-Male,
pubmed-meshheading:20119715-Membrane Proteins,
pubmed-meshheading:20119715-Methotrexate,
pubmed-meshheading:20119715-Permeability,
pubmed-meshheading:20119715-Phosphoproteins,
pubmed-meshheading:20119715-Phosphorylation,
pubmed-meshheading:20119715-Rats,
pubmed-meshheading:20119715-Rats, Wistar,
pubmed-meshheading:20119715-Reactive Oxygen Species,
pubmed-meshheading:20119715-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:20119715-Tight Junctions,
pubmed-meshheading:20119715-Tyrosine
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pubmed:year |
2010
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pubmed:articleTitle |
Zonula Occludens-1 alterations and enhanced intestinal permeability in methotrexate-treated rats.
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pubmed:affiliation |
Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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