| pubmed-article:20118929 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20118929 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:20118929 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:20118929 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:20118929 | lifeskim:mentions | umls-concept:C0007589 | lld:lifeskim |
| pubmed-article:20118929 | lifeskim:mentions | umls-concept:C0034790 | lld:lifeskim |
| pubmed-article:20118929 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:20118929 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:20118929 | lifeskim:mentions | umls-concept:C0079189 | lld:lifeskim |
| pubmed-article:20118929 | lifeskim:mentions | umls-concept:C0008300 | lld:lifeskim |
| pubmed-article:20118929 | lifeskim:mentions | umls-concept:C0033414 | lld:lifeskim |
| pubmed-article:20118929 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:20118929 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:20118929 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:20118929 | lifeskim:mentions | umls-concept:C1521902 | lld:lifeskim |
| pubmed-article:20118929 | lifeskim:mentions | umls-concept:C1511938 | lld:lifeskim |
| pubmed-article:20118929 | lifeskim:mentions | umls-concept:C1881379 | lld:lifeskim |
| pubmed-article:20118929 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:20118929 | pubmed:dateCreated | 2010-2-16 | lld:pubmed |
| pubmed-article:20118929 | pubmed:abstractText | Immature CD4(+)CD8(+) (double-positive (DP)) thymocytes are signaled via T cell antigen receptors (TCRs) to undergo positive selection and become responsive to intrathymic cytokines such as interleukin 7 (IL-7). We report here that cytokine signaling is required for positively selected thymocytes to express the transcription factor Runx3, specify CD8 lineage choice and differentiate into cytotoxic-lineage T cells. In DP thymocytes genetically engineered to be cytokine responsive, IL-7 signaling induced TCR-unsignaled DP thymocytes to express Runx3 and to differentiate into mature CD8(+) T cells, completely circumventing positive selection. We conclude that TCR-mediated positive selection converts DP cells into cytokine-responsive thymocytes, but it is subsequent signaling by intrathymic cytokines that specifies CD8 lineage choice and promotes differentiation into cytotoxic-lineage T cells. | lld:pubmed |
| pubmed-article:20118929 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20118929 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20118929 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20118929 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20118929 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20118929 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20118929 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:20118929 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20118929 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20118929 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:20118929 | pubmed:issn | 1529-2916 | lld:pubmed |
| pubmed-article:20118929 | pubmed:author | pubmed-author:KuboMasatoM | lld:pubmed |
| pubmed-article:20118929 | pubmed:author | pubmed-author:GressRonald... | lld:pubmed |
| pubmed-article:20118929 | pubmed:author | pubmed-author:HennighausenL... | lld:pubmed |
| pubmed-article:20118929 | pubmed:author | pubmed-author:SingerAlfredA | lld:pubmed |
| pubmed-article:20118929 | pubmed:author | pubmed-author:CuiYongzhiY | lld:pubmed |
| pubmed-article:20118929 | pubmed:author | pubmed-author:CatalfamoMart... | lld:pubmed |
| pubmed-article:20118929 | pubmed:author | pubmed-author:ErmanBatuB | lld:pubmed |
| pubmed-article:20118929 | pubmed:author | pubmed-author:FeigenbaumLio... | lld:pubmed |
| pubmed-article:20118929 | pubmed:author | pubmed-author:ParkJung-Hyun... | lld:pubmed |
| pubmed-article:20118929 | pubmed:author | pubmed-author:LucasPhilip... | lld:pubmed |
| pubmed-article:20118929 | pubmed:author | pubmed-author:KimuraMotoko... | lld:pubmed |
| pubmed-article:20118929 | pubmed:author | pubmed-author:GuinterTerryT | lld:pubmed |
| pubmed-article:20118929 | pubmed:author | pubmed-author:AlagAmala SAS | lld:pubmed |
| pubmed-article:20118929 | pubmed:author | pubmed-author:AdoroStanleyS | lld:pubmed |
| pubmed-article:20118929 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20118929 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:20118929 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20118929 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20118929 | pubmed:pagination | 257-64 | lld:pubmed |
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| pubmed-article:20118929 | pubmed:meshHeading | pubmed-meshheading:20118929... | lld:pubmed |
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| pubmed-article:20118929 | pubmed:meshHeading | pubmed-meshheading:20118929... | lld:pubmed |
| pubmed-article:20118929 | pubmed:meshHeading | pubmed-meshheading:20118929... | lld:pubmed |
| pubmed-article:20118929 | pubmed:meshHeading | pubmed-meshheading:20118929... | lld:pubmed |
| pubmed-article:20118929 | pubmed:meshHeading | pubmed-meshheading:20118929... | lld:pubmed |
| pubmed-article:20118929 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20118929 | pubmed:articleTitle | Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells. | lld:pubmed |
| pubmed-article:20118929 | pubmed:affiliation | Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. | lld:pubmed |
| pubmed-article:20118929 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20118929 | pubmed:publicationType | Research Support, N.I.H., Intramural | lld:pubmed |
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