Linked Life Data

20117843

Source:http://linkedlifedata.com/resource/pubmed/id/20117843

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2010-3-9
pubmed:abstractText
The effect of the neuropeptide substance P (SP) on human mast cell (MC) phenotype is poorly understood. In this study, SP effects on human MC expression of the high affinity IgE receptor (FcepsilonRI) were characterized. SP downregulated expression of FcepsilonRI mRNA and protein by approximately 50% and in a concentration dependent manner, the effect was partially mediated by engagement of the neurokinin-1 receptor (NK1R) and resulted in reduced mast cell activation. Sensitization of MC with IgE prior to SP exposure protected MC from SP-mediated FcepsilonRI downregulation. SP release may inhibit MC responses to allergens and these results may have implications in neuroinflammatiion and stress.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1872-8421
pubmed:author
pubmed:copyrightInfo
Crown Copyright 2010. Published by Elsevier B.V. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
30
pubmed:volume
220
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
17-24
pubmed:dateRevised
2011-6-15
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Substance P downregulates expression of the high affinity IgE receptor (FcepsilonRI) by human mast cells.
pubmed:affiliation
Northwestern University Feinberg School of Medicine, Allergy-Immunology Division, 240 E Huron McGaw #M-327, Chicago, IL 60611, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't