Source:http://linkedlifedata.com/resource/pubmed/id/20116984
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2010-3-2
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pubmed:abstractText |
The use of dendritic cells (DCs) for the generation of anti-tumour immunity has been the focus of a vast array of scientific and clinical studies. The ability of DCs to present protein tumour antigens (T-Ags) to CD4(+) and CD8(+) T cells is pivotal to the success of therapeutic cancer vaccines. DC's specialised capacity to cross-present exogenous Ags onto major histocompatibility (MHC) class I molecules for the generation of T-Ag-specific cytotoxic T lymphocytes (CTLs) has made these cells the focal point of vaccine-based immunotherapy of cancer. However, although DC-based strategies can induce T cell responses in cancer patients, recent reviews of clinical studies demonstrate that DC-based approaches have essentially failed to meet their clinical end points. These findings highlight the need to re-evaluate the DC-based vaccine strategies and incorporate recent advancements in DC biology and tumour immunology. The current review considers the issues related to how best to target the Ag-processing pathway of DCs, the role of adjuvants, the appropriate conditioning of the DCs and strategies to overcome tumour-mediated immune escape.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1879-0372
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pubmed:author | |
pubmed:copyrightInfo |
Copyright 2010 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
137-44
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pubmed:meshHeading |
pubmed-meshheading:20116984-Animals,
pubmed-meshheading:20116984-Antigen Presentation,
pubmed-meshheading:20116984-Antigens, Neoplasm,
pubmed-meshheading:20116984-Clinical Trials as Topic,
pubmed-meshheading:20116984-Dendritic Cells,
pubmed-meshheading:20116984-Humans,
pubmed-meshheading:20116984-Neoplasms,
pubmed-meshheading:20116984-Tumor Escape
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pubmed:year |
2010
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pubmed:articleTitle |
Presentation of tumour antigens by dendritic cells and challenges faced.
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pubmed:affiliation |
School of Biological Sciences, The University of Edinburgh, Edinburgh, Scotland, United Kingdom.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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