| pubmed-article:20116099 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20116099 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:20116099 | lifeskim:mentions | umls-concept:C0026986 | lld:lifeskim |
| pubmed-article:20116099 | lifeskim:mentions | umls-concept:C0441471 | lld:lifeskim |
| pubmed-article:20116099 | lifeskim:mentions | umls-concept:C1413947 | lld:lifeskim |
| pubmed-article:20116099 | lifeskim:mentions | umls-concept:C0025723 | lld:lifeskim |
| pubmed-article:20116099 | lifeskim:mentions | umls-concept:C0086860 | lld:lifeskim |
| pubmed-article:20116099 | lifeskim:mentions | umls-concept:C0205214 | lld:lifeskim |
| pubmed-article:20116099 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:20116099 | pubmed:dateCreated | 2010-6-11 | lld:pubmed |
| pubmed-article:20116099 | pubmed:abstractText | The epigenetic changes of tumor suppressor genes are now recognized as an alternative mechanism contributing to the development of myelodysplastic syndrome (MDS). The expression of DNA-damage-inducible transcript 3 (DDIT3) gene has been found down-regulated in myeloid malignancies including MDS. In this study, we performed methylation-specific PCR (MSP) to investigate the methylation status of the CpG island of DDIT3 promoter region in MDS. Aberrant methylation of DDIT3 was detected in 31.8% (21/66) of the cases analyzed. No correlation was found between DDIT3 promoter methylation and clinical parameters and MDS subtypes. Although the estimated 50% survival time of the methylated DDIT3 group was shorter than that of unmethylated group (12.0 months vs. 23.0 months), the difference was not statistically significant (P=0.137). These findings suggest that the hypermethylation of DDIT3 promoter might be one of early events in the development of MDS. | lld:pubmed |
| pubmed-article:20116099 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20116099 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20116099 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20116099 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20116099 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20116099 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20116099 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20116099 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:20116099 | pubmed:issn | 1873-5835 | lld:pubmed |
| pubmed-article:20116099 | pubmed:author | pubmed-author:QianJunJ | lld:pubmed |
| pubmed-article:20116099 | pubmed:author | pubmed-author:JiangLinL | lld:pubmed |
| pubmed-article:20116099 | pubmed:author | pubmed-author:QianZhenZ | lld:pubmed |
| pubmed-article:20116099 | pubmed:author | pubmed-author:WangYa-LiYL | lld:pubmed |
| pubmed-article:20116099 | pubmed:author | pubmed-author:XuWen-RongWR | lld:pubmed |
| pubmed-article:20116099 | pubmed:author | pubmed-author:ZhuZhao-HuiZH | lld:pubmed |
| pubmed-article:20116099 | pubmed:author | pubmed-author:YaoDong-MingD... | lld:pubmed |
| pubmed-article:20116099 | pubmed:copyrightInfo | Copyright (c) 2010 Elsevier Ltd. All rights reserved. | lld:pubmed |
| pubmed-article:20116099 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20116099 | pubmed:volume | 34 | lld:pubmed |
| pubmed-article:20116099 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20116099 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20116099 | pubmed:pagination | 991-4 | lld:pubmed |
| pubmed-article:20116099 | pubmed:meshHeading | pubmed-meshheading:20116099... | lld:pubmed |
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| pubmed-article:20116099 | pubmed:meshHeading | pubmed-meshheading:20116099... | lld:pubmed |
| pubmed-article:20116099 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20116099 | pubmed:articleTitle | Aberrant methylation of DNA-damage-inducible transcript 3 promoter is a common event in patients with myelodysplastic syndrome. | lld:pubmed |
| pubmed-article:20116099 | pubmed:affiliation | Department of Hematology, Affiliated People's Hospital of Jiangsu University, 8 Dianli Road, Zhenjiang, 212002, China. | lld:pubmed |
| pubmed-article:20116099 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20116099 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:1649 | entrezgene:pubmed | pubmed-article:20116099 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:20116099 | lld:entrezgene |
