Source:http://linkedlifedata.com/resource/pubmed/id/20116099
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
2010-6-11
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| pubmed:abstractText |
The epigenetic changes of tumor suppressor genes are now recognized as an alternative mechanism contributing to the development of myelodysplastic syndrome (MDS). The expression of DNA-damage-inducible transcript 3 (DDIT3) gene has been found down-regulated in myeloid malignancies including MDS. In this study, we performed methylation-specific PCR (MSP) to investigate the methylation status of the CpG island of DDIT3 promoter region in MDS. Aberrant methylation of DDIT3 was detected in 31.8% (21/66) of the cases analyzed. No correlation was found between DDIT3 promoter methylation and clinical parameters and MDS subtypes. Although the estimated 50% survival time of the methylated DDIT3 group was shorter than that of unmethylated group (12.0 months vs. 23.0 months), the difference was not statistically significant (P=0.137). These findings suggest that the hypermethylation of DDIT3 promoter might be one of early events in the development of MDS.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
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| pubmed:issn |
1873-5835
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright (c) 2010 Elsevier Ltd. All rights reserved.
|
| pubmed:issnType |
Electronic
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| pubmed:volume |
34
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
991-4
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| pubmed:meshHeading |
pubmed-meshheading:20116099-Adolescent,
pubmed-meshheading:20116099-Adult,
pubmed-meshheading:20116099-Aged,
pubmed-meshheading:20116099-Aged, 80 and over,
pubmed-meshheading:20116099-CpG Islands,
pubmed-meshheading:20116099-DNA, Neoplasm,
pubmed-meshheading:20116099-DNA Damage,
pubmed-meshheading:20116099-DNA Methylation,
pubmed-meshheading:20116099-Female,
pubmed-meshheading:20116099-Humans,
pubmed-meshheading:20116099-Male,
pubmed-meshheading:20116099-Middle Aged,
pubmed-meshheading:20116099-Myelodysplastic Syndromes,
pubmed-meshheading:20116099-Polymerase Chain Reaction,
pubmed-meshheading:20116099-Prognosis,
pubmed-meshheading:20116099-Promoter Regions, Genetic,
pubmed-meshheading:20116099-Survival Rate,
pubmed-meshheading:20116099-Transcription Factor CHOP,
pubmed-meshheading:20116099-Young Adult
|
| pubmed:year |
2010
|
| pubmed:articleTitle |
Aberrant methylation of DNA-damage-inducible transcript 3 promoter is a common event in patients with myelodysplastic syndrome.
|
| pubmed:affiliation |
Department of Hematology, Affiliated People's Hospital of Jiangsu University, 8 Dianli Road, Zhenjiang, 212002, China.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|