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rdf:type |
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lifeskim:mentions |
umls-concept:C0001815,
umls-concept:C0005821,
umls-concept:C0017262,
umls-concept:C0026882,
umls-concept:C0040028,
umls-concept:C0185117,
umls-concept:C0205307,
umls-concept:C0220908,
umls-concept:C0332197,
umls-concept:C0812295,
umls-concept:C1335875,
umls-concept:C1367307,
umls-concept:C1705050,
umls-concept:C1879547,
umls-concept:C2911684
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pubmed:issue |
5
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pubmed:dateCreated |
2010-6-7
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pubmed:abstractText |
To evaluate the frequency of MPL W515L, W515K and S505N mutations in essential thrombocythemia (ET) and primary myelofibrosis (PMF) and to determine whether MPLW515L leads to impaired Mpl expression, constitutive STAT3 and STAT5 activation and enhanced response to thrombopoietin (TPO).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1600-0609
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
84
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
398-405
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pubmed:meshHeading |
pubmed-meshheading:20113333-Adolescent,
pubmed-meshheading:20113333-Adult,
pubmed-meshheading:20113333-Aged,
pubmed-meshheading:20113333-Aged, 80 and over,
pubmed-meshheading:20113333-Base Sequence,
pubmed-meshheading:20113333-Blood Platelets,
pubmed-meshheading:20113333-Blotting, Western,
pubmed-meshheading:20113333-Child,
pubmed-meshheading:20113333-DNA Primers,
pubmed-meshheading:20113333-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:20113333-Female,
pubmed-meshheading:20113333-Flow Cytometry,
pubmed-meshheading:20113333-Humans,
pubmed-meshheading:20113333-Male,
pubmed-meshheading:20113333-Middle Aged,
pubmed-meshheading:20113333-Mutation,
pubmed-meshheading:20113333-Polymerase Chain Reaction,
pubmed-meshheading:20113333-Primary Myelofibrosis,
pubmed-meshheading:20113333-Receptors, Thrombopoietin,
pubmed-meshheading:20113333-STAT3 Transcription Factor,
pubmed-meshheading:20113333-STAT5 Transcription Factor,
pubmed-meshheading:20113333-Thrombocythemia, Essential
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pubmed:year |
2010
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pubmed:articleTitle |
Screening for MPL mutations in essential thrombocythemia and primary myelofibrosis: normal Mpl expression and absence of constitutive STAT3 and STAT5 activation in MPLW515L-positive platelets.
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pubmed:affiliation |
Department of Hematology Research, Instituto de Investigaciones Médicas Alfredo Lanari, University of Buenos Aires, National Council for Scientific and Technological Research (CONICET), Buenos Aires, Argentina.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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