20112359

Source:http://linkedlifedata.com/resource/pubmed/id/20112359

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0002199, umls-concept:C0004358, umls-concept:C0024141, umls-concept:C0030705, umls-concept:C0042333, umls-concept:C0229671, umls-concept:C0332281, umls-concept:C0441655, umls-concept:C1416475, umls-concept:C1708726, umls-concept:C1979963, umls-concept:C2003903, umls-concept:C2673188
pubmed:issue	2
pubmed:dateCreated	2010-2-15
pubmed:abstractText	Interferon-alpha (IFNalpha) is a heritable risk factor for systemic lupus erythematosus (SLE). Genetic variation near IRF7 is implicated in SLE susceptibility. SLE-associated autoantibodies can stimulate IFNalpha production through the Toll-like receptor/IRF7 pathway. This study was undertaken to determine whether variants of IRF7 act as risk factors for SLE by increasing IFNalpha production and whether autoantibodies are important to this phenomenon.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/AI-071651, http://linkedlifedata.com/resource/pubmed/grant/K08 AI083790-01, http://linkedlifedata.com/resource/pubmed/grant/K08-AI-083790, http://linkedlifedata.com/resource/pubmed/grant/L30 AI071651-03, http://linkedlifedata.com/resource/pubmed/grant/RR-025000-02, http://linkedlifedata.com/resource/pubmed/grant/UL1-RR-024999
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/20112359-11303025, http://linkedlifedata.com/resource/pubmed/commentcorrection/20112359-11711679, http://linkedlifedata.com/resource/pubmed/commentcorrection/20112359-12155399, http://linkedlifedata.com/resource/pubmed/commentcorrection/20112359-12499305, http://linkedlifedata.com/resource/pubmed/commentcorrection/20112359-14561795, http://linkedlifedata.com/resource/pubmed/commentcorrection/20112359-14667105, http://linkedlifedata.com/resource/pubmed/commentcorrection/20112359-15188363, http://linkedlifedata.com/resource/pubmed/commentcorrection/20112359-15308637, http://linkedlifedata.com/resource/pubmed/commentcorrection/20112359-15565395, http://linkedlifedata.com/resource/pubmed/commentcorrection/20112359-15657875, http://linkedlifedata.com/resource/pubmed/commentcorrection/20112359-15880830, http://linkedlifedata.com/resource/pubmed/commentcorrection/20112359-16255080, http://linkedlifedata.com/resource/pubmed/commentcorrection/20112359-16297627, http://linkedlifedata.com/resource/pubmed/commentcorrection/20112359-16415888, http://linkedlifedata.com/resource/pubmed/commentcorrection/20112359-16642019, http://linkedlifedata.com/resource/pubmed/commentcorrection/20112359-16729300, http://linkedlifedata.com/resource/pubmed/commentcorrection/20112359-16736505, http://linkedlifedata.com/resource/pubmed/commentcorrection/20112359-16775618, http://linkedlifedata.com/resource/pubmed/commentcorrection/20112359-1690258, http://linkedlifedata.com/resource/pubmed/commentcorrection/20112359-17021721, http://linkedlifedata.com/resource/pubmed/commentcorrection/20112359-17412832, http://linkedlifedata.com/resource/pubmed/commentcorrection/20112359-17581626, http://linkedlifedata.com/resource/pubmed/commentcorrection/20112359-18204446, http://linkedlifedata.com/resource/pubmed/commentcorrection/20112359-18240214, http://linkedlifedata.com/resource/pubmed/commentcorrection/20112359-18525429, http://linkedlifedata.com/resource/pubmed/commentcorrection/20112359-18576315, http://linkedlifedata.com/resource/pubmed/commentcorrection/20112359-18668568, http://linkedlifedata.com/resource/pubmed/commentcorrection/20112359-19109131, http://linkedlifedata.com/resource/pubmed/commentcorrection/20112359-19339987, http://linkedlifedata.com/resource/pubmed/commentcorrection/20112359-449915
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0370605
pubmed:citationSubset	AIM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Antinuclear, http://linkedlifedata.com/resource/pubmed/chemical/Autoantibodies, http://linkedlifedata.com/resource/pubmed/chemical/DNA, http://linkedlifedata.com/resource/pubmed/chemical/IRF7 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Interferon Regulatory Factor-7, http://linkedlifedata.com/resource/pubmed/chemical/Interferon-alpha
pubmed:status	MEDLINE
pubmed:month	Feb
pubmed:issn	0004-3591
pubmed:author	pubmed-author:FranekBeverly SBS, pubmed-author:JollyMeenakshiM, pubmed-author:KariukiSilvia NSN, pubmed-author:MikolaitisRachel ARA, pubmed-author:NiewoldTimothy BTB, pubmed-author:RheeLesleyL, pubmed-author:SalloumRafahR, pubmed-author:UtsetTammy OTO
pubmed:issnType	Print
pubmed:volume	62
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	553-61
pubmed:dateRevised	2011-7-22
pubmed:meshHeading	pubmed-meshheading:20112359-African Americans, pubmed-meshheading:20112359-Antibodies, Antinuclear, pubmed-meshheading:20112359-Autoantibodies, pubmed-meshheading:20112359-DNA, pubmed-meshheading:20112359-European Continental Ancestry Group, pubmed-meshheading:20112359-Gene Frequency, pubmed-meshheading:20112359-Genetic Variation, pubmed-meshheading:20112359-Genotype, pubmed-meshheading:20112359-Hispanic Americans, pubmed-meshheading:20112359-Humans, pubmed-meshheading:20112359-Interferon Regulatory Factor-7, pubmed-meshheading:20112359-Interferon-alpha, pubmed-meshheading:20112359-Lupus Erythematosus, Systemic, pubmed-meshheading:20112359-Risk Factors
pubmed:year	2010
pubmed:articleTitle	Genetic variation at the IRF7/PHRF1 locus is associated with autoantibody profile and serum interferon-alpha activity in lupus patients.
pubmed:affiliation	University of Chicago, Chicago, IL, USA.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural