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pubmed-article:2011133pubmed:abstractTextThe immunomodulatory potency of a series of proline-containing thymopentin (TP-5) analogues was investigated by PFC (in vitro and in vivo) test and by GvH reaction. It was found that the substitution of Asp in position 3 of TP-5 by D-Pro yields a distinctly more active compound than that obtained by substitution of Asp3 by L-Pro. Pro5-TP-5 showed very strongly enhanced activity as compared with TP-5; the effect is especially well obvious in PFC in vitro (15-fold enhancement of activity).lld:pubmed
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pubmed-article:2011133pubmed:articleTitleThe unusually high immunomodulatory activity of thymopentin analogue Pro5-TP-5.lld:pubmed
pubmed-article:2011133pubmed:affiliationInstitute of Immunology and Experimental Therapy, Wroclaw, Poland.lld:pubmed
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