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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
1991-5-8
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pubmed:abstractText |
The immunomodulatory potency of a series of proline-containing thymopentin (TP-5) analogues was investigated by PFC (in vitro and in vivo) test and by GvH reaction. It was found that the substitution of Asp in position 3 of TP-5 by D-Pro yields a distinctly more active compound than that obtained by substitution of Asp3 by L-Pro. Pro5-TP-5 showed very strongly enhanced activity as compared with TP-5; the effect is especially well obvious in PFC in vitro (15-fold enhancement of activity).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0161-5890
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
95-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2011133-Amino Acid Sequence,
pubmed-meshheading:2011133-Animals,
pubmed-meshheading:2011133-Antibody Formation,
pubmed-meshheading:2011133-Graft vs Host Reaction,
pubmed-meshheading:2011133-Hemolytic Plaque Technique,
pubmed-meshheading:2011133-Immunity, Cellular,
pubmed-meshheading:2011133-Mice,
pubmed-meshheading:2011133-Mice, Inbred Strains,
pubmed-meshheading:2011133-Molecular Sequence Data,
pubmed-meshheading:2011133-Oligopeptides,
pubmed-meshheading:2011133-Proline,
pubmed-meshheading:2011133-Spleen,
pubmed-meshheading:2011133-Structure-Activity Relationship,
pubmed-meshheading:2011133-Thymopentin
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pubmed:articleTitle |
The unusually high immunomodulatory activity of thymopentin analogue Pro5-TP-5.
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pubmed:affiliation |
Institute of Immunology and Experimental Therapy, Wroclaw, Poland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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